21226-31-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-bromophenyl)benzenesulfonamide is utilized as a carbonic anhydrase inhibitor for the treatment of conditions such as glaucoma, epilepsy, and altitude sickness. Its inhibitory action on carbonic anhydrase helps in managing the symptoms associated with these conditions by reducing the production of bicarbonate ions, which in turn affects the pH balance and fluid dynamics in the body.
Used in Agrochemical Industry:
In the agrochemical sector, N-(2-bromophenyl)benzenesulfonamide is employed in the synthesis of various agrochemicals, contributing to the development of effective pest control agents and crop protection products.
Used in Dye and Pigment Industry:
N-(2-bromophenyl)benzenesulfonamide is used as a key intermediate in the production of dyes, pigments, and polymers, where its ability to create stable and vibrant colors is highly valued. Its presence in these products enhances their colorfastness and durability, making them suitable for a wide range of applications, including textiles, plastics, and coatings.
Used in Antibacterial and Anti-inflammatory Applications:
N-(2-bromophenyl)benzenesulfonamide has been studied for its antibacterial and anti-inflammatory properties, making it a promising candidate for the development of new drugs and therapies in the medical field. Its potential to combat bacterial infections and reduce inflammation can contribute to improved treatment options for various diseases and conditions.

Upstream product

• 145490-75-1 N-fluorobenzene sulfonamide 
• 98-10-2 benzenesulfonamide 
• 98-09-9 benzenesulfonyl chloride 
• 615-36-1 2-bromoaniline 

Downstream Products

• 151721-54-9 N-(2-bromophenyl)-N-methylbenzenesulfonamide 
• 114996-64-4 3-methylidene-1-(phenylsulfonyl)indoline 
• 114996-66-6 1-phenylsulfonylindoline-3-methanol 
• 114996-65-5 1-(phenylsulfonyl)-3-vinylindoline 
• 114996-67-7 1-Benzenesulfonyl-2,3-dihydro-1H-indole-3-carbaldehyde 
• 1160847-23-3 9-benzenesulfonyl-1-methyl-9H-carbazole 
• 1163305-89-2 5-benzensulfonyl-5,6-dihydro-6-methoxycarbonylmethyl-7-methylphenanthridine 
• 1163305-91-6 5-benzensulfonyl-5,6-dihydro-6-methoxycarbonylmethyl-7,9-dimethylphenanthridine 
• 14925-09-8 2-(N-methylamino)-1,1'-biphenyl 
• 90-10-8 N-methylbenzenesulfonanilide 
• 114996-61-1 N-(2-Bromo-phenyl)-N-prop-2-ynyl-benzenesulfonamide 

Relevant academic research and scientific papers

Rearrangement Reaction Based on the Structure of N-Fluoro- N-alkyl Benzenesulfonamide

A novel rearrangement reaction based on the structure of N-fluoro-N-alkyl benzenesulfonamide was developed. The reaction proceeded readily at 50 °C in formic acid and generated a variety of benzenesulfonamides and aldehydes or ketones simultaneously. The reaction mechanism is believed to be a concerted mechanism that consist of 1,2-aryl migration with the departure of fluorine anion via an SN2 mechanism. This rearrangement reaction features an interesting reaction mechanism, mild reaction conditions, simple operations, and a broad substrate scope.

Palladium-catalyzed desulfitative arylation of sulfonamides with sodium arylsulfinates

A Pd(II)-catalyzed desulfitative arylation protocol between sulfonamides and sodium arylsulfinates was herein reported. The direct arylation reaction was successfully achieved by a Pd(II)/Ag(I)-mediated system without participation of any external ligands with a release of SO2. And different N-aryl sulfonamides were obtained readily in up to 86% yields, exhibiting good functional groups tolerance (25 examples).

A convenient and benign synthesis of sulphonamides in PEG-400

A simple and convenient method is reported for the synthesis of a series of sulphonamides in PEG-400 using potassium carbonate as the base. The reaction is carried out in a heterogeneous medium and consequently product recovery is simple. The desired products with a variety of aromatic amines could be synthesized in a short reaction time in good yield. The PEG could be recovered for reuse.

Synthetic use of 1,1,2,2-tetraphenyldisilane for the preparation of biaryls through the intramolecular free radical ipso-substitution of N-(2-bromoaryl)arenesulfonamides

Treatment of various N-methyl-N-(2-bromoaryl)arenesulfonamides (1a-g, 1i, and 1m) with 1,1,2,2-tetraphenyldisilane and AIBN under heating conditions gave the corresponding biaryl products (2a-g, 2i, and 2m) in moderate yields through the intramolecular radical ipso-substitution. However, N-H free N-(2-bromoaryl)arenesulfonamides 1h and 2-bromoaryl arenesulfonate 1j did not give the corresponding biarys. 1,1,2,2-Tetraphenyldisilane is the most effective reagent for 1,5-ipso-substitution on the sulfonamides among typical radical reagents such as diphenylsilane, tributyltin hydride, tris(trimethylsilyl)silane, and 1,1,2,2-tetraphenyldisilane. Furthermore, 1,1,2,2-tetraphenyldisilane has the advantages of low toxicity, stability, and ease of preparation.

α-fluoromethyl tryptophans via imino ene reaction

A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene in

Chiral sulfoxide ligands bearing nitrogen atoms as stereocontrollable coordinating elements in palladium-catalyzed asymmetric allylic alkylations

Palladium-catalyzed asymmetric allylic alkylations were studied by using chiral sulfoxide ligands bearing nitrogen atoms as coordinating elements, such as chiral α-sulfinylacetamides, β or γ-amino sulfoxides, and β- sulfinyl sulfonamides. The effects of t

Kinetische Verfolgung der Sulfamidbildung mittels quantitativer Differentialthermoanalyse

Die Reaktion zwischen Benzolsulfochlorid und einigen Anilinderivaten kann im Bereich oberchalb 200 K mit der dynamischen Technik der DTA untersucht werden, wobei sich eine Reaktion 2.Ordnung ergibt.Aktivierungsparameter und Reaktionsenthalpien werden durch die Anilinsubstituenten beeinflusst.