212311-87-0Relevant academic research and scientific papers
Thorpe–Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides
O'Neill, Matthew J.,Riesebeck, Tim,Cornella, Josep
, p. 9103 - 9107 (2018)
Presented herein is a general protocol for the alkylation of simple aryl fluorides with unbiased secondary Grignard reagents by means of nickel catalysis. This study revealed a general Thorpe–Ingold effect in the ligand backbone which confers a high degree of selectivity for the secondary carbon center in the C?C coupling event. This protocol is characterized by mild reaction conditions, robustness, and simplicity. Both electron-rich and electron-deficient aryl fluorides are suitable candidates in this transformation. Equally amenable are a variety of heterocycles, permitting the coupling without over alkylation at the electrophilic sites.
Organic phosphorus ligand as well as preparation method and application thereof
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Paragraph 0087-0094, (2022/01/10)
The invention provides a novel phosphine ligand and a preparation method thereof. Fuel ethanol can be obtained from a mixture of synthetic gas and methanol through a one-pot method under the condition that a phosphine ligand and an Rh/Ru bimetallic catalyst precursor are mixed. Through process optimization, the reaction can be carried out under mild conditions, the selectivity is high, and the cost can be greatly reduced. The novel phosphine ligand has good industrialization prospects and huge economic benefits and social values.
