21258-13-9

Upstream product

• 10416-59-8 (Z)-trimethylsilyl N-trimethylsilylacetimidate 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 75-36-5 acetyl chloride 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 16194-64-2 N-(6-fluorobenzo[d]thiazol-2-yl)acetamide 

Relevant academic research and scientific papers

Synthesis of N-benzothiazol-2-yl-amides by Pd-catalyzed C(sp2)-H functionalization

A catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-3-(phenyl)thioureas was achieved in the presence of a palladium catalyst through the C(sp2)-H functionalization/C-S bond formation. This synthetic methodology can produce various N

REACTIONS OF ISOTHIOCYANATES AND ISOCYANATES WITH SOME SILYLATED NITROGEN-CONTAINING NUCLEOPHILES

Aryl isothiocyanates and arylisocyanates react with N,O-bis(trimethylsilyl)acetamide to give N-methyl-N'-arylthioureas and ureas.Also nucleophilic additions of other aprotic nucleophiles (e.g.N-trimethylsilylimidazole, N-trimethylsilylpiperidine and N-trimethylsilylmorpholine) to the N=C=X (X=O,S) group were investigated.