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1,2,2,2-Tetrafluoroethylsulfonyl fluoride, also known as TESF, is a chemical compound characterized by its molecular formula C2F5SO2F. It is a colorless, odorless, and highly reactive liquid with a molecular weight of 174.06 g/mol. TESF is recognized for its utility in organic synthesis, especially in the preparation of fluorinated compounds, and serves as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Due to its high toxicity, TESF necessitates careful handling and stringent safety measures to prevent exposure.

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  • 2127-74-4 Structure
  • Basic information

    1. Product Name: 1,2,2,2-TETRAFLUOROETHYLSULFONYL FLUORIDE
    2. Synonyms: 1,2,2,2-TETRAFLUOROETHYLSULFONYL FLUORIDE;1,2,2,2-Tetrafluoroethylsufonylfluoride;1,2,2,2-TETRAFLUOROETHANESULPHONYLFLUORIDE;1,2,2,2-TETRAFLUOROETHYLSUFONYL FLUORIDE, 97% MIN.;1,2,2,2-tetrafluoroethanesulfonyl fluoride;1H-(Fluorosulphonyl)perfluoroethane;1H-Tetrafluoroethanesulphonyl fluoride
    3. CAS NO:2127-74-4
    4. Molecular Formula: C2HF5O2S
    5. Molecular Weight: 184.09
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2127-74-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 55.7°Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.669g/cm3
    6. Vapor Pressure: 247mmHg at 25°C
    7. Refractive Index: 1.301
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1,2,2,2-TETRAFLUOROETHYLSULFONYL FLUORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,2,2,2-TETRAFLUOROETHYLSULFONYL FLUORIDE(2127-74-4)
    12. EPA Substance Registry System: 1,2,2,2-TETRAFLUOROETHYLSULFONYL FLUORIDE(2127-74-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2127-74-4(Hazardous Substances Data)

2127-74-4 Usage

Uses

Used in Organic Synthesis:
1,2,2,2-Tetrafluoroethylsulfonyl fluoride is used as a fluorination reagent for the preparation of fluorinated compounds. Its reactivity allows for the incorporation of fluorine atoms into various organic molecules, which can significantly alter their chemical and physical properties, enhancing their performance in different applications.
Used in Pharmaceutical Synthesis:
TESF is utilized as a building block in the synthesis of pharmaceuticals. Its unique properties contribute to the development of new drugs with improved efficacy and selectivity. The incorporation of fluorine atoms can enhance the lipophilicity, metabolic stability, and bioavailability of drug molecules, leading to better therapeutic outcomes.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1,2,2,2-Tetrafluoroethylsulfonyl fluoride is employed as a key intermediate in the synthesis of agrochemicals. The introduction of fluorine atoms can improve the pesticidal activity, selectivity, and environmental persistence of these compounds, resulting in more effective and sustainable agricultural solutions.
Used in Fine Chemicals Synthesis:
TESF is also used in the synthesis of fine chemicals, which are high-purity chemicals used in various industries such as fragrances, dyes, and specialty materials. The fluorination capabilities of TESF can provide unique properties to these chemicals, enhancing their performance and expanding their applications.

Check Digit Verification of cas no

The CAS Registry Mumber 2127-74-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,2 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2127-74:
(6*2)+(5*1)+(4*2)+(3*7)+(2*7)+(1*4)=64
64 % 10 = 4
So 2127-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C2HF5O2S/c3-1(2(4,5)6)10(7,8)9/h1H

2127-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,2,2-Tetrafluoroethanesulfonyl fluoride

1.2 Other means of identification

Product number -
Other names 1-H-tetrafluoroethane-2-sulfonyl fluoride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2127-74-4 SDS

2127-74-4Relevant articles and documents

Process for preparing fluorinated beta-sultones

-

, (2008/06/13)

A process allows the preparation of a fluorinated beta-sultone by reacting a fluorinated olefin with oleum.

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