2132-66-3

Basic information

• Product Name: 1-[2-chloro-1-(4-methoxyphenyl)ethenyl]-4-methoxy-benzene
• CAS NO: 2132-66-3
• Molecular Formula: C₁₆H₁₅ClO₂
• Molecular Weight: 274.747
• Mol File: 2132-66-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 408.9°Cat760mmHg
• Flash Point: 155.1°C
• Density: 1.145g/cm³
• CAS DataBase Reference: 1-[2-chloro-1-(4-methoxyphenyl)ethenyl]-4-methoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-chloro-1-(4-methoxyphenyl)ethenyl]-4-methoxy-benzene(2132-66-3)
• EPA Substance Registry System: 1-[2-chloro-1-(4-methoxyphenyl)ethenyl]-4-methoxy-benzene(2132-66-3)

Safety Data

• Hazardous Substances Data: 2132-66-3(Hazardous Substances Data)

Usage

Structure

A derivative of benzene with a chlorine atom and a 4-methoxyphenyl group attached to an ethenyl group

Usage

Organic synthesis and medicinal chemistry as a building block for creating more complex molecules

Applications

Production of pharmaceuticals, agrochemicals, and other fine chemicals

Research significance

Studied for potential therapeutic effects and biological activities, making it a valuable tool in research and drug discovery

Upstream product

• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 
• 100-66-3 methoxybenzene 
• 79-04-9 chloroacetyl chloride 
• 7446-70-0 aluminium trichloride 
• 7388-31-0 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethane 
• 72-43-5 Methoxychlor 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 2132-70-9 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene 

Downstream Products

• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 18523-07-4 1,1-Di-(p-methoxy-phenyl)-2-p-tolylthio-aethylen 
• 4541-92-8 2-Chlor-3,3-bis-<4-methoxy-phenyl>-acrylsaeure 

Relevant articles and documents

Direct electrochemical reduction of 4,4-(2,2,2-trichloroethane-1,1-diyl)bis(methoxybenzene) (methoxychlor) at carbon and silver cathodes in dimethylformamide

Cyclic voltammetry and controlled-potential (bulk) electrolysis have been employed to investigate the electrochemical reduction of 4,4-(2,2,2-trichloroethane-1,1-diyl)bis(methoxybenzene), commonly known as the pesticide methoxychlor, at glassy carbon and silver cathodes in dimethylformamide (DMF) containing 0.050 M tetra-n-butylammonium tetrafluoroborate (TBABF4). Reduction of methoxychlor at both glassy carbon and silver shows four voltammetric peaks, the first three of which are associated with cleavage of carbon–chlorine bonds; the fourth peak is assigned to reduction of 4,4-(ethene-1,1-diyl)bis(methoxybenzene). Bulk electrolyses of methoxychlor at reticulated vitreous carbon and silver mesh cathodes at potentials corresponding to each of the first three voltammetric peaks were conducted; coulometric n values and product distributions (determined by means of GC and GC–MS techniques) depend on potential. In particular, two completely dechlorinated products, namely 4,4-(ethane-1,1-diyl)bis(methoxybenzene) and 4,4-(ethene-1,1-diyl)bis(methoxybenzene) have been identified and quantitated. A mechanistic scheme is proposed to account for the formation of the various products.

A facile and high yielding synthesis of symmetrical and unsymmetrical diarylalkynes using diethyl dichloromethylphosphonate as precursor

The reaction, under internal quench conditions, of diethyl dichloromethylphosphonate and symmetrical or unsymmetrical diaryl ketones in the presence of n-BuLi, leads to the corresponding symmetrical or unsymmetrical diarylalkynes via a Fritsch-Buttenherg-Wiechell rearrangement in a simple, high yielding, one-pot reaction.