213819-19-3

Basic information

• Product Name: 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene
• Synonyms: 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene
• CAS NO: 213819-19-3
• Molecular Weight: 432.678
• Mol File: 213819-19-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene(213819-19-3)
• EPA Substance Registry System: 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene(213819-19-3)

Safety Data

• Hazardous Substances Data: 213819-19-3(Hazardous Substances Data)

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 
• 53-16-7 Estrone 
• 100-39-0 benzyl bromide 

Downstream Products

• 15183-37-6 15α-hydroxyestriol 
• 138743-03-0 (14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one 
• 690996-26-0 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,15-tetraene-17-ol 
• 690996-25-9 17β-acetyloxy-3-benzyloxy-estra-1,3,5(10),15-tetraene 
• 690996-24-8 17-acetyl-3-benzyl estetrol 
• 690996-23-7 17-acetyl estetrol 

Relevant articles and documents

Process for the preparation of estetrol

The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is ―Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative.