21384-58-7

Upstream product

• 2658-24-4 2,2-dimethylaziridine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 122270-59-1 N-<2-(1H-Indol-3-yl)-2-methylpropyl>benzamid 
• 33561-46-5 N-(2-hydroxy-2-methylpropyl)benzamide 
• 709-25-1 N-(2-methylallyl)benzamide 
• 642-29-5 1-benzoylnaphthalene 
• 644-13-3 C₆H₅COC₁₀H₇ 
• 5705-57-7 N-isobutyl-benzamide 
• 5202-81-3 N-(2-methyl-1-propen-1-yl)benzamide 
• 132381-75-0 N-[2-(2-Benzhydryl-phenyl)-2-methyl-propyl]-benzamide 
• 132381-74-9 N-(2,2-Dimethyl-3,3,3-triphenyl-propyl)-benzamide 
• 85809-30-9 N-[2-(4-Benzhydryl-phenyl)-2-methyl-propyl]-benzamide 
• 33561-48-7 5,5-dimethyl-2-phenyl-4,5-dihydrooxazole 
• 55-21-0 benzamide 
• 65-85-0 benzoic acid 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 

Relevant academic research and scientific papers

Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes

We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses radical intermediates for selective C - N bond cleavage and formation.

Experimental and theoretical rearrangement of N-acyl-2,2- dimethylaziridines in acidic medium

The acid isomerization of N-acyl-2,2-dimethylaziridines 1 in concentrated sulfuric acid at room temperature leads to oxazolines 2 but the neutral hydrolysis of 1 in pure water at room temperature leads to amidoalcohols 3. However, the use of aqueous solutions of H2SO4 at different concentrations at room temperature leads to a mixture of oxazolines 2, amidoalcohols 3 and allylamides 4 with yields depending on the acidity of the medium and the nature of the acyl group. A mechanism has been suggested to explain the formation of these three products. DFT calculations employing the Gaussian 09 program with DFT/B3LYP methods and 6-311++G(2d,2p) basis set were carried out which gave the most stable geometry as well as their atomic charge distributions of compounds 1-4. [Figure not available: see fulltext.]

NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES

Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).