21397-40-0

Upstream product

• 101-84-8 diphenylether 
• 620-84-8 4-methyldiphenylamine 
• 98-88-4 benzoyl chloride 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 93-98-1 N-phenyl benzoyl amide 
• 591-50-4 iodobenzene 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 624-31-7 4-tolyl iodide 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 29119-37-7 α,N-diphenyl-α-(4-methyl phenyl) nitrone 

Downstream Products

• 620-84-8 4-methyldiphenylamine 
• 65-85-0 benzoic acid 
• 109866-39-9 anthranilic acid-(phenyl-p-tolyl-amide) 
• 102007-17-0 2-nitro-benzoic acid-(phenyl-p-tolyl-amide) 

Relevant academic research and scientific papers

Efficient synthesis of tertiary acyclic amides by the Chapman rearrangement of aryl benzimidates in ionic liquids

The Chapman rearrangement of aryl N-arylbenzimidates to tertiary acyclic amides is accelerated in ionic liquids and proceeds at lower temperatures as 120-190°C.

A general and efficient CuBr2-catalyzed N-arylation of secondary acyclic amides

A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene. A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene. Copyright

A simple copper-catalyzed synthesis of tertiary acyclic amides

The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.

REARRANGEMENT OF NITRONES TO AMIDES USING CHLOROSULFONYL ISOCYANATE

Reaction of chlorosulfonyl isocyanate (CSI) with nitrones 1a-n and 5a,b has been studied. α,α,N-Triaryl nitrones 1a-n react with CSI to form the N,N-diaryl arylamides 3a-n and 4i-n in good yields.In the case of α-H,α,N-diaryl nitrones 5a,b however, two compounds viz., the rearranged product 11a,b and the 1,4-dihydro tetrazines 10a,b are formed.The effect of substituents on the rearrangement has been studied.It is found that the nature of the substituents has got a profound effect on the rearrangement.We have also noted that the rearrangement is independent of the syn or anti configurations of the nitrones.