2140-29-6

Usage

Uses

Used in Medical Research:
Kojibiose is used as a potential early biochemical indicator for diabetes. In a study examining mice and their levels of kojibiose, it was found that increased levels of this disaccharide may be associated with the development of diabetes.
Used in Food Industry:
Kojibiose can be used as a natural sweetener in the food industry due to its low glycemic index. It is also used as a prebiotic to promote the growth of beneficial bacteria in the gut, which can contribute to improved gut health and overall well-being.
Used in Pharmaceutical Industry:
Kojibiose has potential applications in the pharmaceutical industry as a therapeutic agent for diabetes management. Its ability to act as an early indicator of diabetes may help in the development of diagnostic tools and treatments for the condition.
Used in Cosmetics Industry:
Kojibiose can be used in cosmetics and skincare products for its moisturizing and skin-soothing properties. Its prebiotic effects can also contribute to maintaining a healthy skin microbiome, which is important for overall skin health and appearance.

InChI:InChI=1/C12H22O11/c13-1-3-6(16)8(18)10(11(20)21-3)23-12-9(19)7(17)5(15)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11+,12-/m1/s1

Upstream product

• 57-50-1 Sucrose 
• 50-99-7 D-glucose 
• 63-42-3 D-(+)-lactose 
• 3867-86-5 Brigl's anhydride 
• 113034-57-4 O⁴-β-D-Galactopyranosyl-O²-α-D-glucopyranosyl-D-glucose 
• 108-24-7 acetic anhydride 

Downstream Products

• 3458-28-4 D-Mannose 
• 495-75-0 2,5-anhydro-D-mannose 
• 50-99-7 D-glucose 

Relevant academic research and scientific papers

A SUCROSE PHOSPHORYLASE FOR THE PRODUCTION OF KOJIBIOSE

The present invention relates to the production of the disaccharide kojibiose which is known to be a powerful prebiotic. The invention indeed discloses the generation of genetically modified sucrose phosphorylases which convert -via a transglycosylation reaction- sucrose into kojibiose in a very efficient manner. Hence, the present invention relates to a cost-effective production method of kojibiose which is useful within industry.

Redesign of the Active Site of Sucrose Phosphorylase through a Clash-Induced Cascade of Loop Shifts

Sucrose phosphorylases have been applied in the enzymatic production of glycosylated compounds for decades. However, several desirable acceptors, such as flavonoids or stilbenoids, that exhibit diverse antimicrobial, anticarcinogenic or antioxidant properties, remain poor substrates. The Q345F exchange in sucrose phosphorylase from Bifidobacterium adolescentis allows efficient glucosylation of resveratrol, (+)-catechin and (-)-epicatechin in yields of up to 97 % whereas the wild-type enzyme favours sucrose hydrolysis. Three previously undescribed products are made available. The crystal structure of the variant reveals a widened access channel with a hydrophobic aromatic surface that is likely to contribute to the improved activity towards aromatic acceptors. The generation of this channel can be explained in terms of a cascade of structural changes arising from the Q345F exchange. The observed mechanisms are likely to be relevant for the design of other tailor-made enzymes.