21402-19-7

Basic information

• Product Name: 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE
• Synonyms: 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE;Methylphenylthiazoline-2-thione;3-Methyl-4-phenylthiazole-2(3H)-thione;3-methyl-4-phenyl-2(3H)-Thiazolethione
• CAS NO: 21402-19-7
• Molecular Formula: C₁₀H₉NS₂
• Molecular Weight: 207.32
• Mol File: 21402-19-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 127.0 to 132.0 °C
• Boiling Point: 331.7°C at 760 mmHg
• Flash Point: 154.4°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.723
• CAS DataBase Reference: 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE(21402-19-7)
• EPA Substance Registry System: 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE(21402-19-7)

Safety Data

• Hazardous Substances Data: 21402-19-7(Hazardous Substances Data)

Usage

General Description

3-Methyl-4-phenylthiazoline-2-thione is a heterocyclic chemical compound with the molecular formula C9H7NS. It is a thiazoline derivative and is also known as MPTT. 3-METHYL-4-PHENYLTHIAZOLINE-2-THIONE has been studied for its potential pharmacological properties, including its ability to scavenge free radicals and protect against oxidative stress. It has also been investigated for its potential use as a herbicide. Additionally, 3-Methyl-4-phenylthiazoline-2-thione has been evaluated for its antifungal and antibacterial properties, making it a compound of interest for various industrial and medical applications.

InChI:InChI=1/C10H9NS2/c1-11-9(7-13-10(11)12)8-5-3-2-4-6-8/h2-7H,1H3

Upstream product

• 2103-88-0 4-phenylthiazole-2(3H)-thione 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 532-27-4 1-chloroacetophenone 
• 74-89-5 methylamine 
• 19975-60-1 3-methyl-4-hydroxy-4-phenyl-thiazolidine-2-thione 
• 2103-86-8 2-methylmercapto-4-phenylthiazole 
• 74-88-4 methyl iodide 
• 54199-76-7 3-methyl-4-phenylthiazol-2(3H)-one 

Downstream Products

• 108754-16-1 isopropylidene-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-hydrazine 
• 69809-55-8 2-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-1-phenyl-ethanone 
• 69809-59-2 2-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-1-phenyl-ethanethione 
• 77008-08-3 C₁₀H₈⁽²⁾HNS₂ 

Relevant articles and documents

Synthesis and Evaluation of 2(3H)-Thiazole Thiones as Tyrosinase Inhibitors

A series of 2(3H)-thiazole thiones 3-5 was synthesized and evaluated for tyrosinase inhibition and DPPH radical scavenging activities. Among them, 3-methyl-4-phenyl-2(3H)-thiazole thione (4a) showed good tyrosinase inhibitory activity, even better than that of the well-known tyrosinase inhibitor, namely, kojic acid. From the structure-activity point of view, although it was found that the phenolic hydroxyl group in prototype 3-5 might contribute to the scavenging activity against DPPH radicals, there was no correlation between the potency of tyrosinase inhibition and the presence of the phenolic moiety. The in silico ADME-Tox screening revealed that the drug-likeness and drug-score values of the most potent compound 4a were significantly higher than those of kojic acid. Copyright