2103-88-0

Basic information

• Product Name: 2-MERCAPTO-4-PHENYLTHIAZOLE
• Synonyms: TIMTEC-BB SBB008121;2(3H)-Thiazolethione, 4-phenyl-;4-phenyl-2(3h)-thiazolethion;4-Phenyl-2-mercaptothiazole;4-phenyl-2-thiazolethio;4-Thiazoline-2-thione, 4-phenyl-;AKOS BBS-00006683;4-PHENYLTHIAZOLE-2-THIOL
• CAS NO: 2103-88-0
• Molecular Formula: C₉H₇NS₂
• Molecular Weight: 193.29
• EINECS: 218-274-7
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 2103-88-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 167-172 °C
• Boiling Point: 343.263 °C at 760 mmHg
• Flash Point: 161.4 °C
• Appearance: /
• Density: 1.288 g/cm³
• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: 2-8°C
• PKA: 7.84±0.40(Predicted)
• BRN: 128288
• CAS DataBase Reference: 2-MERCAPTO-4-PHENYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MERCAPTO-4-PHENYLTHIAZOLE(2103-88-0)
• EPA Substance Registry System: 2-MERCAPTO-4-PHENYLTHIAZOLE(2103-88-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: XJ5123450
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 2103-88-0(Hazardous Substances Data)

Usage

Uses

4-Phenyl-2-mercaptothiazole is used in the synthesis of novel azabicyclo derivatives.

Synthesis Reference(s)

Synthetic Communications, 23, p. 1455, 1993 DOI: 10.1080/00397919308011236

InChI:InChI=1/C9H7NS2/c11-9-10-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H,10,11)

Upstream product

• 513-74-6 ammonium dithiocarbamate 
• 70-11-1 α-bromoacetophenone 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 79069-32-2 phenyl(phenylethynyl)iodonium tosylate 
• 333-20-0 potassium thioacyanate 
• 17356-08-0 thiourea 
• 98-86-2 acetophenone 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 60-29-7 diethyl ether 
• 532-27-4 1-chloroacetophenone 
• 53983-40-7 triethylammonium dithiocarbamate 
• 507-09-5 thioacetic acid 
• 1826-23-9 2-chloro-4-phenylthiazole 
• 857618-06-5 dithiocarbamic acid phenacyl ester 

Downstream Products

• 76098-78-7 2-(benzylthio)-4-phenylthiazole 
• 101423-29-4 2-((4-chlorobenzyl)thio)-4-phenylthiazole 
• 15208-27-2 (4-phenyl-thiazol-2-ylmercapto)-acetic acid 
• 5316-75-6 1-phenyl-2-(4-phenyl-thiazol-2-ylsulfanyl)-ethanone 
• 2103-86-8 2-methylmercapto-4-phenylthiazole 
• 23349-44-2 bis(4-phenylthiazol-2-yl) disulfide 
• 97620-28-5 4-phenyl-2-p-tolyldisulfanyl-thiazole 
• 94375-01-6 trithiocarbonic acid bis-(4-phenyl-thiazol-2-yl) ester 
• 97238-14-7 2-(4-chloro-2-nitro-phenyldisulfanyl)-4-phenyl-thiazole 
• 97833-27-7 2-(2-chloro-phenyldisulfanyl)-4-phenyl-thiazole 
• 101092-38-0 5-[2-(3-methyl-thiazolidin-2-ylidene)-ethylidene]-4-phenyl-5H-thiazole-2-thione 
• 94464-36-5 5-[2-(3-ethyl-3H-benzothiazol-2-ylidene)-ethylidene]-4-phenyl-5H-thiazole-2-thione 
• 94542-83-3 5-[2-(3-ethyl-3H-benzooxazol-2-ylidene)-ethylidene]-4-phenyl-5H-thiazole-2-thione 
• 94210-45-4 5,5'-dichloro-4,4'-diphenyl-2,2'-disulfanediyl-bis-thiazole 

Relevant articles and documents

Hypervalent iodine in synthesis; 60: A novel method for the synthesis of 2-mercaptothiazoles by cyclocondensation of alkynyl(phenyl)iodonium salts and ammonium dithiocarbamate

A novel method for the synthesis of 2-mercaptothiazoles is achieved by cyclocondensation of alkynyl(phenyl)iodonium salts with ammonium dithiocarbamate. A reaction mechanism is proposed.

Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3: H)-thiones employing flow processing

A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.