136122-48-0Relevant articles and documents
New Process for the Synthesis of Imidazopyridine Derivatives as Potent Orally Active Thromboxane A2 Receptor Antagonists
Nikolai, E.,Claude, S.,Teulon, J. M.
, p. 73 - 76 (2007/10/02)
A new synthetic route to prepare the 4-pyridin-2-yl>-3,3-dimethylbutanoic acid (UP 116-77) is described.UP 116-77 is a potent orally active TXA2/PGH2 receptor antagonist currently under pharmacological investigation.Its development needed a suitable synthesis for industrial processing.The cyclization of 3-amino-5-chloro-2-(4-chlorophenyl)methylaminopyridine 4 with 3,3-dimethylglutaric anhydride in refluxing acetic acid affords a new efficient and simple way to UP 116-77 and subsequently to various 2-substituted imidazopyridine derivatives.