136122-48-0

Upstream product

• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 104-86-9 4-chlorobenzylamine 
• 21427-61-2 5-chloro-3-nitropyridin-2-ol 

Downstream Products

• 147643-72-9 4-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl]-butyric acid ethyl ester 
• 136145-12-5 ethyl 4-<3-<(4-chlorophenyl)methyl>-6-chloroimidazo<4,5-b>pyridin-2-yl>-3,3-dimethylbutanoate 
• 147643-73-0 2-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl]-2-methyl-propionic acid ethyl ester 
• 136122-55-9 6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridine-2-thiol 
• 136122-46-8 β,β-dimethyl-6-chloro-3-((4-chlorophenyl)methyl)-3H-imidazo(4,5-b)pyridine-2-butanoic acid 
• 136122-52-6 3-amino-5-chloro-2-<(4-chlorophenyl)methyl>aminopyridine 

Relevant academic research and scientific papers

New Process for the Synthesis of Imidazopyridine Derivatives as Potent Orally Active Thromboxane A2 Receptor Antagonists

A new synthetic route to prepare the 4-pyridin-2-yl>-3,3-dimethylbutanoic acid (UP 116-77) is described.UP 116-77 is a potent orally active TXA2/PGH2 receptor antagonist currently under pharmacological investigation.Its development needed a suitable synthesis for industrial processing.The cyclization of 3-amino-5-chloro-2-(4-chlorophenyl)methylaminopyridine 4 with 3,3-dimethylglutaric anhydride in refluxing acetic acid affords a new efficient and simple way to UP 116-77 and subsequently to various 2-substituted imidazopyridine derivatives.

Synthesis and Structure - Activity Relationships of Novel Benzimidazole and Imidazopyridine Acid Derivatives as Thromboxane A2 Receptor Antagonists

A series of 1-benzylbenzimidazole and 3-benzylimidazopyridine substituted in the 2-position by an alkanoic or mercaptoalkanoic acid chain was synthesized for evaluation as potential thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonists.T