2143-80-8

Basic information

• Product Name: (3E)-4-(2-Fluorophenyl)but-3-en-2-one
• Synonyms: (3E)-4-(2-Fluorophenyl)but-3-en-2-one;4-(2-Fluorophenyl)but-3-en-2-one
• CAS NO: 2143-80-8
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.1762632
• Mol File: 2143-80-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 259.9°Cat760mmHg
• Flash Point: 104.4°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: (3E)-4-(2-Fluorophenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-4-(2-Fluorophenyl)but-3-en-2-one(2143-80-8)
• EPA Substance Registry System: (3E)-4-(2-Fluorophenyl)but-3-en-2-one(2143-80-8)

Safety Data

• Hazardous Substances Data: 2143-80-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9FO/c1-8(12)6-7-9-4-2-3-5-10(9)11/h2-7H,1H3/b7-6+

Upstream product

• 446-46-8 2-fluorobenzenediazonium tetrafluoroborate 
• 78-94-4 methyl vinyl ketone 
• 348-54-9 2-Fluoroaniline 
• 445-27-2 2'-Fluoroacetophenone 
• 67-64-1 acetone 
• 446-52-6 2-Fluorobenzaldehyde 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 

Downstream Products

• 1236557-02-0 (S)-9-(1-(2-fluorophenyl)-3-oxobutyl)anthracen-10(9H)-one 
• 1258206-96-0 C₁₂H₁₂FN₃O 
• 1241388-93-1 5-(1-(2-fluorophenyl)-3-oxobutyl)furan-2(5H)-one 
• 1254200-34-4 (R)-dibenzyl 2-(1-(2-fluorophenyl)-3-oxobutyl)malonate 
• 1332338-89-2 3-(2-fluorophenyl)-2',5-dioxospiro[cyclohexane-1,3'-indoline]-2,2-dicarbonitrile 
• 102821-72-7 5-(2-fluorophenyl)-cyclohexane-1,3-dione 
• 1397692-08-8 (5S,6S,10S)-ethyl 10-(2-fluorophenyl)-4,8-dioxo-3-phenyl-2-thioxo-1-thia-3-azaspiro[4.5]decane-6-carboxylate 

Relevant articles and documents

RhIII-Catalyzed Synthesis of Highly Substituted 2-Pyridones using Fluorinated Diazomalonate

A RhIII-catalyzed strategy was developed for the rapid construction of highly substituted 2-pyridone scaffolds using α,β-unsaturated oximes and fluorinated diazomalonate. The reaction proceeds through direct, site-selective alkylation based on migratory insertion and subsequent cyclocondensation. A wide substrate scope with different functional groups was explored. The requirement of fluorinated diazomalonate was explored for this transformation. The developed methodology was further extended with the synthesis of the bioactive compound.

Dehydrozingerone derivative and preparation method and application thereof

The invention provides a dehydrozingerone derivative as shown in the description. R-R are each independently selected from hydrogen or halogen or a nitro group or an alkyl group or a substitutedalkoxy group or an alkoxy group or a hydroxyl group; the substituent in the substituted alkoxy group is selected from one or multiple of halogen, a nitro group and a hydroxyl group; R and R areeach independently selected from hydrogen or halogen or nitrogen-containing heterocycle; R is selected from an alkyl group or an alkoxy group or a substituted alkoxy group; the substituent in thesubstituted alkyl group is selected from one or multiple of halogen, a nitro group and a hydroxyl group; X is selected from a hetero atom or a hydroxylamine group. The dehydrozingerone derivative hasbroad-spectrum activity against plant pathogenic fungi and bacteria, and has certain nematicidal activity, and is a lead compound with the broad biological activity.

Rh(III)-Catalyzed Enaminone-Directed Alkenyl C-H Activation for the Synthesis of Salicylaldehydes

A Rh(III)-catalyzed enaminone-directed alkenyl C-H coupling with alkynes for the synthesis of salicylaldehyde derivatives is reported. This represents a unique example of benzene ring framework formation through a transition-metal-catalyzed, directed C-H activation strategy. The two incorporated reactive functionalities, aldehyde and hydroxy groups, provide convenient synthetic handles for further structural elaboration.