214550-36-4Relevant academic research and scientific papers
Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light
Li, Xipan,Liang, Kangjiang,Liu, Qian,Shen, Lei,Wei, Delian,Xia, Chengfeng,Zheng, Liyan
, p. 6996 - 7002 (2020/07/23)
The phenolate anion was discovered as a new photocatalyst with strong reduction potentials. Under visible light irradiation, the phenolate anion enabled the reduction of (hetero)aryl halides (including electron-rich aryl chlorides) to (hetero)aryl radicals through single electron transfer. Based on this new photocatalyst, a novel and efficient photocatalytic protocol for the intermolecular oxyarylation of olefins with aryl halides and TEMPOH was developed. The developed three-component coupling reaction proceeded under redox-neutral reaction conditions with stable and readily available synthons and exhibited broad substrate scope. The utility of this process was further highlighted by the diversified chemical manipulation of the resulting oxyarylation products and the late-stage modification of active pharmaceutical ingredients.
A case of pictet-spengler revisited: Application to the synthesis of dihydroisocoumarins
Choukchou-Braham,Mostefa-Kara,Cheikh,Didi,Villemin
, p. 169 - 178 (2007/10/03)
The reaction of Pictet-Spengler was revisited, and its modified conditions were applied to develop a general methodology toward the synthesis of dihydroisocoumarins containing a no-electron rich aromatic ring.
Improved procedure for 3,4-dihydro-1H-2-benzopyran ring closure. A general access to 3-substituted isochromanes
Antonioletti, Roberto,Bovicelli, Paolo,Crescenzi, Benedetta,Lupattelli, Paolo
, p. 6751 - 6752 (2007/10/03)
A general method for the ring closure of 1-substituted 2-(- hydroxymethyl)-phenylethanols to 3-substituted isochromanes using p-TsOH supported on silica gel is reported.
