5422-47-9

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-phenylethanol
• CAS NO: 5422-47-9
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• Mol File: 5422-47-9.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 354.3°C at 760 mmHg
• Flash Point: 152.7°C
• Density: 1.112g/cm³
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-phenylethanol(5422-47-9)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-phenylethanol(5422-47-9)

Safety Data

• Hazardous Substances Data: 5422-47-9(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)-2-phenylethanol, also known as p-methoxyphenyl-phenylethanol or PMPOH, is a chemical compound that belongs to the family of phenylethanolamines. It is a colorless to pale yellow liquid with a floral, rose-like odor. PMPOH is commonly used as a fragrance ingredient in perfumes, soaps, and cosmetics due to its pleasant aroma. It is also used as a flavoring agent in food products and as a chemical intermediate in the synthesis of pharmaceuticals and other organic compounds. PMPOH has been found to have antioxidant and antimicrobial properties, and it is generally considered to have low toxicity. However, like any chemical compound, proper handling and storage procedures should be followed to ensure safe use.

Upstream product

• 14310-21-5 1-(4-methoxyphenyl)-2-phenylethane 
• 100-44-7 benzyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 122-78-1 phenylacetaldehyde 
• 918314-81-5 1-chloro-1-(4-methoxyphenyl)-2-phenylethane 
• 1401229-25-1 1-(1-(4-methoxyphenyl)-2-phenylethoxy)-2,2,6,6-tetramethylpiperidine 
• 108-90-7 chlorobenzene 
• 637-69-4 4-Methoxystyrene 
• 87100-28-5 pinacol benzylboronate 
• 2372-33-0 chlorodimethyl(4-methoxyphenyl)silane 
• 31593-52-9 2-benzyl-1,3-dithiane 
• 935263-23-3 (R)-N-4-methoxybenzylidene-2-methylpropane-2-sulfinamide 
• 770-09-2 benzyltrimethylsilane 

Downstream Products

• 1694-19-5 E-1-(phenyl)-2-(4'-methoxyphenyl)ethene 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 123-11-5 4-methoxy-benzaldehyde 
• 140-11-4 Benzyl acetate 
• 113160-01-3 1-[2-methoxy-2-(4-methoxyphenyl)ethyl]benzene 
• 100-52-7 benzaldehyde 
• 100-09-4 4-methoxybenzoic acid 
• 214550-36-4 (+/-)-3-(4'-methoxyphenyl)isochroman 
• 918314-81-5 1-chloro-1-(4-methoxyphenyl)-2-phenylethane 
• 37568-81-3 3,4-dihydro-3-(4-methoxyphenyl)-1H-2-benzopyran-1-one 
• 1016896-38-0 (R)-1-acetoxy-2-phenyl-1-(4-methoxyphenyl)ethane 
• 22711-21-3 4-methoxybenzil 
• 1694-19-5 p-methoxystilbene 
• 121-98-2 methyl 4-methoxybenzoate 

Relevant articles and documents

Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light

The phenolate anion was discovered as a new photocatalyst with strong reduction potentials. Under visible light irradiation, the phenolate anion enabled the reduction of (hetero)aryl halides (including electron-rich aryl chlorides) to (hetero)aryl radicals through single electron transfer. Based on this new photocatalyst, a novel and efficient photocatalytic protocol for the intermolecular oxyarylation of olefins with aryl halides and TEMPOH was developed. The developed three-component coupling reaction proceeded under redox-neutral reaction conditions with stable and readily available synthons and exhibited broad substrate scope. The utility of this process was further highlighted by the diversified chemical manipulation of the resulting oxyarylation products and the late-stage modification of active pharmaceutical ingredients.

Nitrogen Dioxide Catalyzed Aerobic Oxidative Cleavage of C(OH)–C Bonds of Secondary Alcohols to Produce Acids

Stable organic nitroxyl radicals are an important class of catalysts for oxidation reactions, but their wide applications are hindered by their steric hinderance, high cost, complex operation, and separation procedures. Herein, NO2 in DMSO is shown to effectively catalyze the aerobic oxidative cleavage of C(OH)?C bonds to form a carboxylic group, and NO2 was generated in situ by decomposition of nitrates. A diverse range of secondary alcohols were selectively converted into acids in excellent yields in this transition-metal-free system without any additives. Preliminary results also indicate its applicability to depolymerize recalcitrant macromolecular lignin. Detail studies revealed that NO2 from nitrates promoted the reaction, and NO2 served as hydrogen acceptor and radical initiator for the tandem oxidative reaction.

Direct Conversion of Alcohols into Alkenes by Dehydrogenative Coupling with Hydrazine/Hydrazone Catalyzed by Manganese

We have developed unprecedented methods for the direct transformation of primary alcohols to alkenes in the presence of hydrazine, and for the synthesis of mixed alkenes by the reaction of alcohols with hydrazones. The reactions are catalyzed by a manganese pincer complex and proceed in absence of added base or hydrogen acceptors, liberating dihydrogen, dinitrogen, and water as the only byproducts. The proposed mechanism, based on preparation of proposed intermediates and control experiments, suggests that the transformation occurs through metal–ligand cooperative N?H activation of a hydrazone intermediate.