21477-44-1

Upstream product

• 13343-40-3 (2,2-difluoro-1-cyclopropyl)benzene 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 
• 873-66-5 1-propenylbenzene 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 1199-77-5 α-methylcinnamic acid 
• 24116-79-8 2-fluoro-3-phenyl-2-propen-1-yl bromide 
• 826-08-4 2-fluoro 3-phenyl prop-2-ene 1-ol (Z) 
• 350-99-2 ethyl (E/Z)-2-fluoro-3-phenylprop-2-enoate 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Asymmetric Synthesis of Alkyl Fluorides: Hydrogenation of Fluorinated Olefins

The development of new general methods for the synthesis of chiral fluorine-containing molecules is important for several scientific disciplines. We herein disclose a straightforward method for the preparation of chiral organofluorine molecules that is ba

Catalytic C-F bond activation of geminal difluorocyclopropanes by nickel(i) complexes via a radical mechanism

Nickel(ii) fluorido complexes bearing NNN-pincer ligands were found to be catalysts in the hydrodefluorination of geminal difluorocyclopropanes which undergo ring-opening to form the corresponding monofluoroalkenes in good yield and high Z-selectivities. Evidence for a radical based mechanism involving nickel(i) and nickel hydrido complexes as key intermediates was obtained in the corresponding stoichiometric reactions.

Decarboxylation and fluorination method for cinnamic acid and derivative thereof

The invention discloses a decarboxylation and fluorination method for cinnamic acid and a derivative thereof. The method comprises the steps that the cinnamic acid or the derivative thereof reacts with 1-chloromethyl-4-fluorophenyl-1,4-diazabicyclo[2.2.2]octane bis(tetrafluoroboric acid) salt and an alkali compound in one pot, and the fluorination product (mainly a cis-form structure product) of the cinnamic acid or the derivative thereof is obtained. The method fills in the technical blank on the decarboxylation and fluorination method for carboxylic acid connected with SP2 hybridization carbon atoms in the prior art, and is easy to operate, short in process and high in product yield, and the industrial production requirement is met.

Transition metal free decarboxylative fluorination of cinnamic acids with selectfluor

Herein we report a transition metal free decarboxylative fluorination of cinnamic acids with selectfluor. A range of functionalized cinnamic acid derivatives reacted with 2 equiv. of selectfluor and 4 equiv. of base in hydrophobic solvent and water to afford β-fluorostyrene with good yield and Z-stereoselectivity. Kinetic study was conducted.

Direct fluorination of styrenes

We have developed a practical method to synthesize fluorostyrene compounds. A mild and regioselective mono-fluorination reaction occurred smoothly for various di- and trisubstituted styrenes in the presence of RuCl3 and N-fluorobenzenesulfonimide (NFSI). A tandem alkyne hydroarylation-olefin fluorination reaction was also developed using an Au catalyst.

Thermal decomposition of alkenyliodonium tetrafluoroborates: A novel route to fluoroalkenes

Alkenyl(phenyl)iodonium tetrafluoroborates dissolved in chloroform, or in the solid state, decompose thermally at 60°C to yield fluoroalkenes and iodobenzene as major products via an S(N)1- or S(N)2-type reaction within the ion pair of the substrates. (C) 2000 Elsevier Science Ltd.

N-fluorosulfonimides and their application as fluorinating agents

The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.

CATALYTIC HYDROGENOLYSIS OF 1,1-DIFLUORO-2-PHENYL-AND 1,1-DIFLUORO-3-METHYL-2-PHENYLCYCLOPROPANE.

The title compounds were hydrogenolyzed over PdO or Raney nickel. The C//2-C//3 bond of the cyclopropane ring underwent cleavage exclusively over both catalyts. The contribution of the fluorine substituent to the lengthening and weakening the C//2-C//3 bond of the cyclopropane ring seems to become a dominant factor in regioselectivity.