215258-04-1

Basic information

• Product Name: 2-Propenoic acid, 3-[4-(acetylamino)phenyl]-, ethyl ester, (2E)-
• CAS NO: 215258-04-1
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol File: 215258-04-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-(acetylamino)phenyl]-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-(acetylamino)phenyl]-, ethyl ester, (2E)-(215258-04-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-(acetylamino)phenyl]-, ethyl ester, (2E)-(215258-04-1)

Safety Data

• Hazardous Substances Data: 215258-04-1(Hazardous Substances Data)

Upstream product

• 622-50-4 4-Acetamido-1-iodobenzene 
• 140-88-5 ethyl acrylate 
• 5048-82-8 (E)-ethyl 3-(4-aminophenyl)acrylate 
• 108-24-7 acetic anhydride 
• 383663-05-6 ethyl 3-(4-acetylaminophenyl)-3-hydroxypropionate 
• 124-63-0 methanesulfonyl chloride 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 1071-46-1 hydrogen ethyl malonate 
• 122-85-0 para-acetamidobenzaldehyde 

Downstream Products

• 88368-65-4 ethyl 3-(4-acetamidophenyl)propionate 
• 199678-84-7 (E)-3-[4-(Acetyl-methyl-amino)-phenyl]-acrylic acid 
• 215258-28-9 (E)-3-[4-(Acetyl-methyl-amino)-phenyl]-acrylic acid ethyl ester 
• 67249-02-9 (E)-3-(4-acetylaminophenyl)acrylic acid 

Relevant articles and documents

Palladium chloride catalyzed photochemical Heck reaction

PdCl2 catalyzed carbon-carbon bond formation (Heck reaction) between substituted aryl halides and olefins was carried out without a ligand, under irradiation with UV-visible light. The results demonstrated that UV-visible light accelerated the rate of the reaction, leading to an excellent yield of corresponding products. The recovered palladium nanoparticles could be thermally recycled several times. PdCl2 gave excellent conversion up to the fifth addition of substrate.

Organocatalytic decarboxylative Doebner-Knoevenagel reactions between arylaldehydes and monoethyl malonate mediated by a bifunctional polymeric catalyst

A bifunctional polystyrene bearing both DMAP and piperidine groups has been prepared and used as an organocatalyst for decarboxylative Doebner-Knoevenagel reactions of arylaldehydes and monoethyl malonate. Isolated yields of the resulting cinnamates were very high, and in all cases only the E-isomer was detected. When a polystyrene catalyst functionalized with only DMAP or piperidine groups was used in these reactions, catalysis was much less efficient. Furthermore, catalysis using a combination of the monofunctional polymers was also less efficient than with the bifunctional polystyrene. Thus, it appears that there is a synergistic effect obtained by co-locating the two different catalytic amine groups on the same polymer backbone. Georg Thieme Verlag Stuttgart · New York.

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.