2155-98-8

Basic information

• Product Name: Isoxazole, 3,5-dimethyl-4-(4-nitrophenyl)-
• CAS NO: 2155-98-8
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.212
• Mol File: 2155-98-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3,5-dimethyl-4-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3,5-dimethyl-4-(4-nitrophenyl)-(2155-98-8)
• EPA Substance Registry System: Isoxazole, 3,5-dimethyl-4-(4-nitrophenyl)-(2155-98-8)

Safety Data

• Hazardous Substances Data: 2155-98-8(Hazardous Substances Data)

Upstream product

• 1160169-37-8 1-(3-methyl-2-(4-nitrophenyl)-2H-azirin-2-yl)ethanone 
• 123-54-6 acetylacetone 
• 636-98-6 p-nitrobenzene iodide 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 586-78-7 para-nitrophenyl bromide 
• 89185-83-1 3-(4-nitrophenyl)-pentane-2,4-dione 
• 4345-47-5 3-phenyl-pentane-2,4-dione monooxime 
• 5910-25-8 3-phenylpentane-2,4-dione 
• 79-24-3 Nitroethane 
• 555-16-8 4-nitrobenzaldehdye 
• 4345-46-4 3,5-dimethyl-4-phenyl-isoxazole 
• 1160169-23-2 (Z)-4-amino-3-(4-nitrophenyl)pent-3-en-2-one 

Downstream Products

• 2155-99-9 4-(3,5-dimethylisoxazol-4-yl)aniline 
• 3020-60-8 4-(3,5-dimethyl-isoxazol-4-yl)-N,N,N-trimethyl-anilinium; iodide 
• 2154-80-5 4-(3,5-dimethylisoxazol-4-yl)-N,N-dimethylaniline 
• 2156-01-6 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-acetamide 
• 2156-00-5 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-benzamide 
• 2156-02-7 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-diacetamide 

Relevant articles and documents

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Ligand-free-palladium-catalyzed direct 4-arylation of isoxazoles using aryl bromides

4-rylisoxazoles can be easily prepared by a palladium-catalysed C-H bond activation/arylation of 3,5-disubstituted isoxazoles using aryl or heteroaryl bromides. Good yields were generally obtained by using 0.1-0.5 mol-% of the airstable PdCl2 c