2155-98-8

Upstream product

• 79-24-3 Nitroethane 
• 555-16-8 4-nitrobenzaldehdye 
• 1160169-37-8 1-(3-methyl-2-(4-nitrophenyl)-2H-azirin-2-yl)ethanone 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 123-54-6 acetylacetone 
• 1160169-23-2 (Z)-4-amino-3-(4-nitrophenyl)pent-3-en-2-one 
• 89185-83-1 3-(4-nitrophenyl)-pentane-2,4-dione 
• 5910-25-8 3-phenylpentane-2,4-dione 
• 4345-46-4 3,5-dimethyl-4-phenyl-isoxazole 
• 4345-47-5 3-phenyl-pentane-2,4-dione monooxime 

Downstream Products

• 2155-99-9 4-(3,5-dimethylisoxazol-4-yl)aniline 
• 2156-02-7 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-diacetamide 
• 2156-00-5 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-benzamide 
• 2156-01-6 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-acetamide 
• 2154-80-5 4-(3,5-dimethylisoxazol-4-yl)-N,N-dimethylaniline 
• 3020-60-8 4-(3,5-dimethyl-isoxazol-4-yl)-N,N,N-trimethyl-anilinium; iodide 

Relevant academic research and scientific papers

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.

One-pot synthesis of isoxazoles from enaminones: An application of Fe(II) as the catalyst for ring expansion of 2H-azirine intermediates

We report an application of FeCl2 as an inexpensive, nontoxic, and efficient catalyst in a clean ring expansion reaction of 2H-azirine derivatives, an intermediate formed through the PhI(OAc)2-mediated azirination of readily availabl

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.

Ligand-free-palladium-catalyzed direct 4-arylation of isoxazoles using aryl bromides

4-rylisoxazoles can be easily prepared by a palladium-catalysed C-H bond activation/arylation of 3,5-disubstituted isoxazoles using aryl or heteroaryl bromides. Good yields were generally obtained by using 0.1-0.5 mol-% of the airstable PdCl2 c

Simple conversion of enamines to 2h-azirines and their rearrangements under thermal conditions

A variety of substituted enamine derivatives were first found to be conveniently converted to the corresponding 2H-azirines mediated by phenyliodine (III) diacetate (PIDA). The formed 2-aryl-2W-azirines could be applied in the synthesis of indole-3-carbon

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Simple Synthesis of Symmetrical 4-Substituted 3,5-Dialkylisoxazoles

A number of symmetrical 4-substituted 3,5-dialkylrsoxazoles have been prepared by treatment of aromatic aldehydes with nitroalkanes and aqueous sodium hydroxide.