2155-99-9

Upstream product

• 5910-25-8 3-phenylpentane-2,4-dione 
• 123-54-6 acetylacetone 
• 89185-83-1 3-(4-nitrophenyl)-pentane-2,4-dione 
• 636-98-6 p-nitrobenzene iodide 
• 16114-47-9 3,5-dimethylisoxazole-4-boronic acid 
• 540-37-4 p-aminoiodobenzene 
• 4345-47-5 3-phenyl-pentane-2,4-dione monooxime 
• 4345-46-4 3,5-dimethyl-4-phenyl-isoxazole 
• 2155-98-8 3,5-dimethyl-4-(4-nitrophenyl)isoxazole 

Downstream Products

• 2154-80-5 4-(3,5-dimethylisoxazol-4-yl)-N,N-dimethylaniline 
• 3020-60-8 4-(3,5-dimethyl-isoxazol-4-yl)-N,N,N-trimethyl-anilinium; iodide 
• 2156-02-7 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-diacetamide 
• 2156-01-6 N-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-acetamide 

Relevant academic research and scientific papers

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains an unvalidated antiviral target. A major challenge of specifically targeting HIV RNase H arises from the general lack of selectivity over RT polymerase (pol) and integrase (IN) strand transfer (ST) inhibitions. We report herein the synthesis and biochemical evaluations of three novel 3-hydroxypyrimidine-2,4-dione (HPD) subtypes carefully designed to achieve selective RNase H inhibition. Biochemical studies showed the two subtypes with an N-1 methyl group (9 and 10) inhibited RNase H in low micromolar range without siginificantly inhibiting RT polymerase, whereas the N-1 unsubstituted subtype 11 inhibited RNase H in submicromolar range and RT polymerase in low micromolar range. Subtype 11 also exhibited substantially reduced inhibition in the HIV-1 INST assay and no significant cytotoxicity in the cell viability assay, suggesting that it may be amenable to further structure-activity relationship (SAR) for identifying RNase H inhibitors with antiviral activity.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.