215674-15-0

Basic information

• Product Name: Pyridine, 2-fluoro-4-(iodomethyl)- (9CI)
• Synonyms: Pyridine, 2-fluoro-4-(iodomethyl)- (9CI);2-fluoro-4-(iodomethyl)pyridine
• CAS NO: 215674-15-0
• Molecular Formula: C6H5FIN
• Molecular Weight: 237.0134732
• Product Categories: PYRIDINE;Non-Chiral heterocyclic compounds
• Mol File: 215674-15-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 261.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.942±0.06 g/cm3(Predicted)
• PKA: -0.82±0.26(Predicted)
• CAS DataBase Reference: Pyridine, 2-fluoro-4-(iodomethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-fluoro-4-(iodomethyl)- (9CI)(215674-15-0)
• EPA Substance Registry System: Pyridine, 2-fluoro-4-(iodomethyl)- (9CI)(215674-15-0)

Safety Data

• Hazardous Substances Data: 215674-15-0(Hazardous Substances Data)

Upstream product

• 461-87-0 2-fluoro-4-methylpyridine 
• 220587-59-7 2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate 
• 155705-46-7 2-fluoro-pyridin-4-ylmethyl chloride 
• 131747-60-9 (2-fluoropyridin-4-yl)methanol 

Downstream Products

• 160588-45-4 DMP 543 

Relevant articles and documents

Efficient pyridinylmethyl functionalization: Synthesis of 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an acetylcholine release enhancing agent

2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methane-sulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the cognition enhancer drug candidate 1. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis.