21585-27-3Relevant academic research and scientific papers
Convenient synthesis of 1,4-di(alkyldithioate) piperazines
Li, Run-Tao,Cai, Meng-Shen
, p. 65 - 71 (1999)
A series of 1,4-di(alkyldithioate)-piperazine were prepared from the reaction of anhydrous piperazine with carbon disulfide and different alkyl halide in the presence of anhydrous potassium phosphate under mild condition in good to excellent yields.
Cyclic ammonium salts of dithiocarbamic acid: stable alternative reagents for the synthesis of S-alkyl carbodithioates from organyl thiocyanates in water
Biswas, Kinkar,Ghosh, Sujit,Ghosh, Pranab,Basu, Basudeb
, p. 361 - 376 (2016/07/23)
ABSTRACT: Carbodithioate esters are important functional organosulfur compounds widely used in diverse fields such as pharmaceuticals, agrochemicals and material sciences. Common preparative methods include reaction of alkyl halides, carbon disulfide and bases under both metal-free and metal-catalyzed conditions. However, organyl thiocyanates have not been previously explored, possibly because of their conversion to organyl disulfides under basic conditions. Here, we report an efficient and practical method for the preparation of libraries of carbodithioate esters from organyl thiocyanates by reacting with cyclic amine-based dithiocarbamic acid salts in water. The protocol is found to be applicable in general to various thiocyanates such as benzyl/aroyl methyl/cinnamyl and so on. Other notable features include no by-products such as disulfides, metal- and alkali-free, aqueous conditions, and finally easy and near-quantitative formation of cyclic amine-based dithiocarbamic acid salt as a stable alternative reagent.
A unique dithiocarbamate chemistry during design & synthesis of novel sperm-immobilizing agents
Jangir, Santosh,Bala, Veenu,Lal, Nand,Kumar, Lalit,Sarswat, Amit,Kumar, Lokesh,Kushwaha, Bhavana,Singh, Pratiksha,Shukla, Praveen Kumar,Maikhuri, Jagdamba Prasad,Gupta, Gopal,Sharma, Vishnu Lal
, p. 3090 - 3099 (2014/05/06)
1-Substituted piperazinecarbodithioates were obtained by an unusual removal of CS2 in benzyl substituted dithiocarbamate derivatives under acid and basic conditions during design and synthesis of 1,4-(disubstituted) piperazinedicarbodithioates as double edged spermicides. A plausible mechanism for CS2 removal has been proposed. All synthesized compounds were subjected to spermicidal, antitrichomonal and antifungal activities. Twenty-one compounds irreversibly immobilized 100% sperm (MEC, 0.06-31.6 mM) while seven compounds exhibited multiple activities. Benzyl 4-(2-(piperidin-1-yl)ethyl) piperazine-1-(carbodithioate) (18) and 1-benzyl 4-(2-(piperidin-1-yl)ethyl) piperazine-1,4-bis(carbodithioate) (24) exhibited appreciable spermicidal (MEC, 0.07 and 0.06 mM), antifungal (MIC, 0.069-0.14 and >0.11 mM) and antitrichomonal (MIC, 1.38 and 0.14 mM) activities. The probable mode of action of these compounds seems to be through sulfhydryl binding which was confirmed by fluorescence labeling of sperm thiols.
A NEW SYNTHETIC PROCEDURE FOR THE CONVENIENT PREPARATION OF THIOCARBAMOYL CHLORIDES AND THE NOVEL BIS-THIOCARBAMOYL CHLORIDES
Skorini, Samal Jens i,Senning, Alexander
, p. 539 - 542 (2007/10/02)
Treatment of N-silylamines with excess thiophosgene affords thiocarbamoyl chlorides in good yields and excellent purity.This method was also suitable for preparing the first bis-thiocarbamoyl chlorides from N,N'-bis(trimethylsilyl)-diamines.Bis-thiocarbam
