21596-41-8 Usage
Uses
Used in Organic Synthesis:
2-(bromomethyl)-1,3-diphenylprop-2-en-1-one serves as a building block in organic synthesis, facilitating the creation of a wide array of organic compounds. Its versatility in this field is attributed to its ability to participate in numerous chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(bromomethyl)-1,3-diphenylprop-2-en-1-one is utilized for the development of new drugs. Its potential applications in medicinal chemistry are vast, as it has been studied for properties such as antimicrobial, anti-inflammatory, and anticancer activities. These properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Medicinal Chemistry for Drug Development:
2-(bromomethyl)-1,3-diphenylprop-2-en-1-one is employed as a key intermediate in the synthesis of pharmaceuticals. Its antimicrobial, anti-inflammatory, and anticancer properties are of particular interest, as they indicate its potential in creating effective treatments for a range of medical issues.
Used as a Reagent for Further Functionalization Reactions:
The bromomethyl group present in 2-(bromomethyl)-1,3-diphenylprop-2-en-1-one makes it a useful reagent for additional functionalization reactions. This feature broadens its applicability in chemical research and development, allowing for the modification and enhancement of its properties to suit specific needs across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 21596-41-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,5,9 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21596-41:
(7*2)+(6*1)+(5*5)+(4*9)+(3*6)+(2*4)+(1*1)=108
108 % 10 = 8
So 21596-41-8 is a valid CAS Registry Number.
21596-41-8Relevant academic research and scientific papers
Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO 2-) Donors as Potential Anticerebral Ischemia Agents
Wu, Jianbing,Yin, Wei,Huang, Zhangjian,Zhang, Yinqiu,Jia, Jian,Cheng, Huimin,Kang, Fenghua,Huang, Kai,Sun, Tao,Tian, Jide,Xu, Xiaojun,Zhang, Yihua
, p. 10919 - 10933 (2021/08/16)
The treatment of ischemic stroke (IS) remains a big challenge in clinics, and it is urgently needed to develop novel, safe, and effective medicines against IS. Here, we report the design, synthesis, and biological evaluation of organic NO2- donors as potential agents for the treatment of IS. The representative compound 4a was able to slowly generate low concentrations of NO2- by reaction with a thiol-containing nucleophile, and the NO2- was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway. Treatment with 4a at 2 h before or after ischemia mitigated the ischemia/reperfusion-induced brain injury in middle cerebral artery occlusion (MCAO) rats by producing NO and enhancing Nrf2 signaling. Furthermore, 4a significantly promoted endothelial cell proliferation and angiogenesis within the ischemic penumbra. Our findings suggest that this type of NO2- donors, like 4a, may be valuable to fight IS and other ischemic diseases.
