21639-02-1Relevant academic research and scientific papers
Preparation of N-acyl derivatives of amino acids from acyl chlorides and amino acids in the presence of cationic surfactants. A variation of the Schotten-Baumann method of benzoylation of amino acids
Jursic,Neumann
, p. 555 - 564 (2001)
A very efficient method for the preparation of N-acylamino acids from the corresponding acyl chloride and amino acid is described. Amino acids, potassium carbonate, acyl chloride, and a catalytic amount of cationic surfactants were mixed in tetrahydrofuran and refluxed without ever obtaining a clear reaction mixture. After hot filtration, the product was isolated from the hot tetrahydrofuran solution in very high or almost quantitative yields.
Condensation of α-Amino Acid with Amine in the Absence of a Coupling Agent
Yamaguchi, Jun-Ichi,Nagai, Shinya,Fukuoka, Emi,Suyama, Takayuki
, p. 830 - 831 (2007/10/03)
Treatment of N-(4-nitrophenoxycarbonyl)amino acid with an equimolar amount of amine in the absence of a coupling agent gave the corresponding α-amino acid amide in high yield.
