2166-07-6

Basic information

• Product Name: Pyridazine, 3,6-bis(4-methoxyphenyl)-
• CAS NO: 2166-07-6
• Molecular Formula: C18H16N2O2
• Molecular Weight: 292.337
• Mol File: 2166-07-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Pyridazine, 3,6-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridazine, 3,6-bis(4-methoxyphenyl)-(2166-07-6)
• EPA Substance Registry System: Pyridazine, 3,6-bis(4-methoxyphenyl)-(2166-07-6)

Safety Data

• Hazardous Substances Data: 2166-07-6(Hazardous Substances Data)

Upstream product

• 65263-11-8 3,6-bis(4-methoxyphenyl)-2,7-dihydro-1,4,5-thiadiazepine 
• 17283-98-6 (Z,Z)-1,4-di(acetylthio)-1,4-di(p-methoxyphenyl)-1,3-butadiene 
• 17284-12-7 (Z,Z)-1,4-di(p-methoxyphenyl)-1,3-butadiene-1,4-dithiol 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 141-30-0 3,6-dichlorpyridazine 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 135034-10-5 3-chloro-6-iodopyridazine 
• 93298-06-7 2-bromo-1-(4-methoxy-phenyl)-ethanone semicarbazone 
• 20177-84-8 1-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)-2-oxo-ethylsulfanyl]-ethanone 
• 183211-07-6 (Z,Z)-1,4-di(2-nitrophenyldithio)-1,4-di[p-methoxyphenyl]-1,3-butadiene 
• 183211-03-2 (Z,Z)-1,4-di(t-butylthio)-1,4-di(p-methoxyphenyl)-1,3-butadiene 

Downstream Products

• 66575-48-2 3,6-bis-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyridazine 

Relevant articles and documents

A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines

A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.

Pd-catalyzed chemoselective cross-coupling reaction of triaryl- or triheteroarylbismuth compounds with 3,6-dihalopyridazines

The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. Copyright

Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate

A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.