2166-07-6

Upstream product

• 52866-26-9 ((E)-Buta-1,3-dienyl)-diethyl-amine 
• 14141-66-3 3,6-bis-(4-methoxy-phenyl)-[1,2,4,5]tetrazine 
• 139943-10-5 trans-1-(dimethylamino)-1,3-butadiene 
• 141-30-0 3,6-dichlorpyridazine 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 16212-87-6 3,6-di(p-methoxyphenyl)-1,2-dithiine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 135034-10-5 3-chloro-6-iodopyridazine 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 20177-84-8 1-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)-2-oxo-ethylsulfanyl]-ethanone 
• 183211-07-6 (Z,Z)-1,4-di(2-nitrophenyldithio)-1,4-di[p-methoxyphenyl]-1,3-butadiene 
• 183211-03-2 (Z,Z)-1,4-di(t-butylthio)-1,4-di(p-methoxyphenyl)-1,3-butadiene 
• 17284-07-0 (Z,Z)-1,4-di(benzylthio)-1,4-di(p-methoxyphenyl)-1,3-butadiene 

Downstream Products

• 66575-48-2 3,6-bis-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyridazine 

Relevant academic research and scientific papers

A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines

A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.

B(C6F5)3-catalyzed metal-free hydrogenation of 3,6-diarylpyridazines

This paper describes the first metal-free hydrogenation of 3,6-diarylpyridazines, which was successfully realized using B(C6F5)3 as a catalyst. A variety of 1,4,5,6-tetrahydropyridazine derivatives were furnished in 85-95%

Pd-catalyzed chemoselective cross-coupling reaction of triaryl- or triheteroarylbismuth compounds with 3,6-dihalopyridazines

The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. Copyright

Highly selective mono-substitution in Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine with organozinc compounds

Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate

A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.

1,2-Dithiines and precursors, XVI: Synthesis, structure, and reactivity of non-anellated 1,2-dithiines

Various monocyclic 1,2-dithiines 6a,b,d-t were prepared via (Z,Z)-1,4-difunctionalized butadienes (4-11,19,20). A twisted cyclic structure A is unequivocally proved rather than of the ringopened valence isomer B. The reactivity of these 1,2-dithiines is d

Preparation of 3,6-Disubstituted Pyridazines from 3-Thiapentane-1,5-diones via 2,7-Dihydro-1,4,5-thiadiazepines

A series of 3-thiapentane-1,5-diones condense with hydrazine in the presence of a catalytic amount of p-toluenesulfonic acid in refluxing ethanol to give 2,7-dihydro-1,4,5-thiadiazepines in excellent yields.Thermal decomposition of the latter compounds in

A NOVEL SYNTHESIS OF PYRIDAZINES: INVERSE ELECTRON DEMAND DIELS-ALDER REACTION OF TETRAZINES WITH ACYCLIC DIENAMINES

Tetrazines (1) when reacted wuth dienamines (2) furnished, pyridazines (3) and (4) in good yields.This appears to be the first case wherein the intermediate bipyridazines (8) have fragmented to (3) and (4) prefering rupture of carbon-carbon bonds.

A CONVENIENT SYNTHESIS OF 3,6-DIARYLPYRIDAZINES

Cathodic reductions of phenacylbromides semicarbazones lead to 1,4-diaryl-1,4-butanedione disemicarbazones which give the corresponding 3,6-diarylpyridazines directly by heating.