21731-57-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(Methylsulphonyl)benzene-1,2-diamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-(Methylsulphonyl)benzene-1,2-diamine is utilized as a building block for the creation of unique chemical compounds with specific applications, leveraging its distinctive molecular structure.
Used in Anti-inflammatory Applications:
4-(Methylsulphonyl)benzene-1,2-diamine is explored as an anti-inflammatory agent, potentially mitigating inflammation through its interaction with biological systems, although further research is required to confirm its efficacy and safety in this context.
Used in Anti-cancer Research:
4-(Methylsulphonyl)benzene-1,2-diamine has shown promise as an anti-cancer agent in early research studies. It may contribute to the development of novel cancer treatments by targeting specific pathways or mechanisms involved in cancer progression, although more extensive research is needed to validate these findings and optimize its use in oncology.

Upstream product

• 21731-56-6 1-Amino-4-methylsulphonyl-2-nitrobenzene 
• 23153-09-5 1-amino-4-methylthio-2-nitrobenzene 
• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 54029-50-4 acetic acid-(4-methanesulfonyl-2-nitro-anilide) 
• 121444-20-0 5-(methylsulfonyl)-2-nitroaniline 
• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 2369-11-1 5-fluoro-2-nitroaniline 
• 31431-10-4 2-amino-4-methylthio-1-nitrobenzene 

Downstream Products

• 54393-93-0 1,2-bis-(3-carbomethoxy-2-thioureido)-4-methylsulfonylbenzene 
• 1192251-51-6 2-biphenyl-4-yl-6-(methylsulfonyl)-1H-benzimidazole 
• 1192251-64-1 6-(methylsulfonyl)-2-[4-(2-thienyl)phenyl]-1H-benzimidazole 
• 1192251-88-9 {4-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]phenyl}boronic acid 
• 1438246-03-7 C₂₅H₂₄N₄O₅S 
• 1438246-34-4 C₂₅H₂₄N₄O₅S 
• 1192251-77-6 6-(methylsulfonyl)-2-(6-phenylpyridazin-3-yl)-1H-benzimidazole 
• 1192251-78-7 6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole 
• 1192251-87-8 2-(4-bromophenyl)-6-(methylsulfonyl)-1H-benzimidazole 

Relevant academic research and scientific papers

Benzimidazole derivatives, their preparation and their application in medicine and pharmacology (by machine translation)

The invention relates to a new control or inhibit indocyanine 2, 3 - dioxygenase (IDO) activity of the benzimidazole derivatives, their preparation and their application in medicine and pharmacology. Specifically, the invention relates to a compound of general formula (I) compound of formula and its pharmaceutically acceptable salt, containing the compound or its pharmaceutically acceptable salt of the pharmaceutical composition, the use of the compound or its pharmaceutically acceptable salts for treating and/or preventing the relevance of the IDO-mediated disease, especially a tumor of the method and the compound or its pharmaceutically acceptable salts thereof. The invention also relates to the compound or its pharmaceutically acceptable salt or containing the compound or its pharmaceutically acceptable salts for the preparation of a pharmaceutical composition for treating and/or preventing the relevance of the IDO-mediated disease, in particular of the use of the drug in the tumor. Wherein the general formula (I) of each substituent is as defined in the specification. (by machine translation)

COMPOUNS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

IMIDAZOLE DERIVATIVES

Described herein are compounds of formula I. The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

Process for the manufacture of benzimidazolones-(2)

Process for the manufacture of benzimidazolones-(2) wherein an o-phenylenediamine is reacted with optionally alkylated urea in the ratio of 1 to 1.3 moles per mole o-phenylenediamine in an organic solvent which has a solubility in water of not more than 5 g/l and has a boiling point above 100° C, at a temperature between 100° and 200° C.

5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity

Carbalkoxythioureidobenzene derivatives represented by the following formula: STR1 where R is a lower alkyl group having 1 to 4 carbon atoms; R1 is --SR2, --SOR2, --SO2 R2, --OR2, --SCN, --SC(O)NR3 R4, or --M'(CH2)n MR7 where n is 1-4; R2 is lower alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, aralkyl or aryl, provided that when R1 is --SO2 R2, R2 is not aralkyl or phenyl; R3 and R4 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, --NHC(O) (CH2)m COOH where m is 1-6, or --NHC(S)NHCOOR; M and M' are independently O, S or STR2 and R7 is lower alkyl having 1 to 4 carbon atoms or aryl. The R1 substitution is either at the 4- or 5-position. The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.

Substituted 1-sulfonylbenzimidazoles

Certain 1-sulfonyl-2,5(6)-substituted-benzimidazole compounds are useful as antiviral agents.