21731-56-6

Basic information

• Product Name: 4-mesyl-2-nitroaniline
• Synonyms: 4-mesyl-2-nitroaniline;(4-mesyl-2-nitro-phenyl)amine;2-Amino-5-(methylsulphonyl)nitrobenzene, 4-Amino-3-nitrophenyl methyl sulphone;4-Methanesulfonyl-2-nitroaniline
• CAS NO: 21731-56-6
• Molecular Formula: C₇H₈N₂O₄S
• Molecular Weight: 216.21442
• EINECS: 244-550-1
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 21731-56-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200-202°C
• Boiling Point: 463.3 °C at 760 mmHg
• Flash Point: 234 °C
• Appearance: /
• Density: 1.487g/cm³
• Vapor Pressure: 9.16E-09mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C(protect from light)
• PKA: -3.88±0.10(Predicted)
• CAS DataBase Reference: 4-mesyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-mesyl-2-nitroaniline(21731-56-6)
• EPA Substance Registry System: 4-mesyl-2-nitroaniline(21731-56-6)

Safety Data

• Hazardous Substances Data: 21731-56-6(Hazardous Substances Data)

Usage

General Description

4-Mesyl-2-nitroaniline is a chemical compound that is used in various chemical reactions due to its chemical properties. 4-mesyl-2-nitroaniline consists of a benzene ring, which is one of the fundamental structures in organic chemistry, substituted with a mesyl group (SO3CH3), an amino group (NH2), and a nitro group (NO2). The mesyl group is a good leaving group in nucleophilic substitution reactions, while the nitro group is electron withdrawing, making the benzene ring less reactive towards electrophilic aromatic substitution. The amino group may be involved in reactions such as diazotization or amide formation. The compound is usually available as an off-white to beige solid. Due to the nature of its constituents, careful handling of the compound is necessary to avoid risks associated with its toxicity and potential reactivity.

InChI:InChI=1/C7H8N2O4S/c1-14(12,13)5-2-3-6(8)7(4-5)9(10)11/h2-4H,8H2,1H3

Upstream product

• 23153-09-5 1-amino-4-methylthio-2-nitrobenzene 
• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 60854-81-1 2-chloro-4-(methylsulfonyl)-1-nitrobenzene 
• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 22821-80-3 N-(4-methanesulfonylphenyl)acetamide 
• 20945-69-1 4-methanesulfonyl-1-methoxy-2-nitro-benzene 
• 54029-50-4 acetic acid-(4-methanesulfonyl-2-nitro-anilide) 

Downstream Products

• 1192251-78-7 6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole 
• 1192251-77-6 6-(methylsulfonyl)-2-(6-phenylpyridazin-3-yl)-1H-benzimidazole 
• 1192251-88-9 {4-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]phenyl}boronic acid 
• 1192251-64-1 6-(methylsulfonyl)-2-[4-(2-thienyl)phenyl]-1H-benzimidazole 
• 1192251-51-6 2-biphenyl-4-yl-6-(methylsulfonyl)-1H-benzimidazole 
• 1192251-87-8 2-(4-bromophenyl)-6-(methylsulfonyl)-1H-benzimidazole 
• 21731-57-7 5-methylsulphonyl-1,2-phenylenediamine 
• 20951-32-0 5-Methanesulfonyl-2-methylsulfanyl-phenylamine 
• 20945-67-9 4-Methanesulfonyl-1-methylsulfanyl-2-nitro-benzene 
• 97-10-9 2-nitro-4-methylsulphonyl-phenol 
• 2976-32-1 1-methanesulfonyl-3-nitro-benzene 

Relevant articles and documents

NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

Substituted (alkoxycarbonylthioureido)-(acylamino)-benzene derivatives

Benzene derivatives of the formula: STR1 wherein R1 represents alkyl, R2 represents a group --SR3, --SOR3, --SO2 R3, --OR3, --SCONH2, --SCN or --T(CH2)m T1 R4 [wherein R3 represeents alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, unsubstituted or substituted aryl, or cycloalkylalkyl, R4 represents hydrogen or alkyl, T and T1 each represent oxygen, sulphur or sulphinyl, and m is an integer from 1 to 7] whose position on the benzene ring is either para to the group --NHCSNHCOOR1 or para to the group --NHCOAZ, A represents a bivalent straight-chain aliphatic hydrocarbon radical of 1 to 4 carbon atoms or a said hydrocarbon radical substituted by at least one methyl group, and Z represents a group of the formula:- STR2 wherein R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl or phenylalkyl, and R7 represents hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are attached form a 5-,6- or 7-membered heterocyclic ring optionally substituted by alkyl group(s), and X- represents a pharmaceutically acceptable anion, are new compounds useful as anthelmintics and antifungal agents.