217451-41-7

Upstream product

• 42472-69-5 4-ethynylacetophenone 
• 129660-01-1 4,6-Dichloro-2H-pyran-2-on 
• 109613-00-5 4-acetophenyl triflate 
• 50-00-0 formaldehyd 
• 108-18-9 diisopropylamine 
• 863098-32-2 1-(4-(bromoethynyl)phenyl)-ethan-1-one 
• 1086430-08-1 1-[4-(iodoethynyl)phenyl]ethanone 
• 13329-40-3 4-Iodoacetophenone 
• 1066-54-2 trimethylsilylacetylene 
• 99-90-1 para-bromoacetophenone 
• 552-16-9 ortho-nitrobenzoic acid 
• 14235-81-5 4-Ethynylaniline 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 217451-32-6 μ-[1,4-bis(4-acetylphenyl)-1,3-butadiene-1,2,3,4-tetrathiolato]-bis[(η(5)-cyclopentadienyl)cobalt(III)] 

Relevant academic research and scientific papers

Copper Nanoparticles on Ordered Mesoporous Carbon Nitride Support: a Superior Catalyst for Homo- and Cross-Coupling of Terminal Alkynes under Base-Free Conditions

A novel ordered mesoporous carbon nitride (OMCN) was synthesized as a functionalized support with 2,4,6-trichloro-1,3,5-triazine and benzidine as starting materials in the presence of SBA-15 as a template. Copper nanoparticles were then loaded on the C–N material to achieve a novel nanocomposite catalyst (Cu NPs-OMCN). The nanocomposite was utilized as a highly efficient catalyst for homo- and cross-coupling of terminal alkynes under base-free conditions in ethanol, and various symmetrical and unsymmetrical 1,3-diynes were obtained with good to excellent yields. Moreover, based on this reaction, a one-pot approach to synthesize 2,5-disubstituted thiophenes and furans from terminal alkynes were developed. Furthermore, the heterogeneous catalyst could be recovered and reused conveniently for several times with satisfactory yields.

Synthesis of Aryl Alkynes via Copper Catalyzed Decarboxylative Alkynylation of 2-Nitrobenzoic Acids

An efficient protocol for the synthesis of internal aryl alkynes was achieved via Cu-catalyzed decarboxylative cross-coupling reactions, and to the best of our knowledge, this is the first example of a Cu-catalyzed decarboxylative alkynylation of benzoic acids with terminal alkynes. This approach utilizes simple Cu salt as catalyst and O2, an abundant, clean, and green material, as the oxidant. The reaction tolerates various functional groups, and a variety of internal aryl alkynes were synthesized in 46-83% yields.

The symmetry of the 1, 4 - disubstituted - 1, 3 - butadiyne preparation method

The invention discloses a preparation method of symmetric 1,4-disubstituted-1,3-diacetylene. Homocoupling of alkyne is carried out in a solvent in the presence of an alkali with silver as a catalyst to obtain the symmetric 1,4-disubstituted-1,3-diacetylen

Synthesis of N = 8 Armchair Graphene Nanoribbons from Four Distinct Polydiacetylenes

We demonstrate a highly efficient thermal conversion of four differently substituted polydiacetylenes (PDAs 1 and 2a-c) into virtually indistinguishable N = 8 armchair graphene nanoribbons ([8]AGNR). PDAs 1 and 2a-c are themselves easily access

Copper Catalysis for Selective Heterocoupling of Terminal Alkynes

A Cu-catalyzed selective aerobic heterocoupling of terminal alkynes is disclosed, which enables the synthesis of a broad range of unsymmetrical 1,3-diynes in good to excellent yields. The results disprove the long-held belief that homocouplings are exclusively favored in the Glaser-Hay reaction.

Copper(i) chloride catalysed room temperature Csp-Csp homocoupling of terminal alkynes mediated by visible light

We developed a technique mediated by visible light for the aerobic homocoupling of terminal alkynes to synthesize 1,3-conjugated diynes using a copper(i) chloride catalyst at room temperature. Compared with previously reported thermal processes, this photochemical method is simple, uses only mild reaction conditions, produces high yields and works well for substrates with electron-withdrawing groups without the need for bases/ligands, oxidants or palladium catalysts.

First report of a nano-Cu2O-catalyzed protocol for homo-coupling reaction of terminal alkynes in water/ionic liquid medium

A new, efficient and green protocol for the nano-Cu2O-catalyzed homo-coupling reaction of terminal alkynes has been developed, using water/ionic liquid as an environmentally friendly solvent. Moreover, the system also allows the synthesis of unsymmetric 1,3-diynes by cross-coupling of two different terminal alkynes. It is noteworthy that the nano-Cu2O-catalyzed methodology is a good supplement to copper catalyst for the Glaser-type homo-coupling reaction. Copyright

Visible-light-activated copper(i) catalyzed oxidative Csp-Csp cross-coupling reaction: Efficient synthesis of unsymmetrical conjugated diynes without ligands and base

A novel visible-light-promoted copper-catalysed process for the Csp-Csp cross-coupling reaction of terminal alkynes at room temperature is described. The current photochemical method is simple, highly functional group compatible, and more viable towards the construction of bio-active 1,3-unsymmetrical conjugated diynes without the need of bases/ligands, additives and expensive palladium/gold catalysts.

Silver-catalyzed Glaser coupling of alkynes

Excellent yields were obtained from the silver nitrate-catalyzed homocoupling reaction of alkynes in N,N-dimethylformamide using triphenylphosphine as ligand. This safe and simple silver catalytic system has been employed in a safe and efficient protocol

Synthesis of 1,4-diarylsubstituted 1,3-diynes through ligand-free copper-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids

An efficient method of ligand-free Cu-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids was developed. When CuI was employed as the catalyst and I2 as the oxidant, the decarboxylative homocoupling reaction for Csp/s