75883-03-3

Upstream product

• 99-90-1 para-bromoacetophenone 
• 1066-54-2 trimethylsilylacetylene 
• 109613-00-5 4-acetophenyl triflate 
• 13329-40-3 4-Iodoacetophenone 
• 250643-77-7 tris(2-(trimethylsilyl)ethynyl)indium 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 6224-91-5 trimethyl(prop-1-ynyl)silane 
• 29619-42-9 1,1'-[ethyne-1,2-diylbis(4,1-phenylene)]diethanone 
• 75-77-4 chloro-trimethyl-silane 
• 42472-69-5 4-ethynylacetophenone 
• 186689-49-6 2-(4-Acetyl-phenyl)-3-trimethylsilanyl-buta-1,3-diene-1,4-dione 

Downstream Products

• 110598-54-4 1-(4-(1-(4-methoxyphenyl)vinyl)phenyl)ethanone 
• 110598-40-8 1-{4-[(E)-1-(4-Methoxy-phenyl)-2-trimethylsilanyl-vinyl]-phenyl}-ethanone 
• 110598-47-5 1-{4-[(Z)-2-(4-Methoxy-phenyl)-2-trimethylsilanyl-vinyl]-phenyl}-ethanone 
• 217451-41-7 1,1′-(buta-1,3-diyne-1,4-diylbis(4,1-phenylene))bis(ethan-1-one) 
• 259110-13-9 4-(4-[1,3]dioxan-2-yl-phenyl)-2-(4-trimethylsilanylethynyl-phenyl)-but-3-yn-2-ol 
• 29619-42-9 1,1'-[ethyne-1,2-diylbis(4,1-phenylene)]diethanone 
• 123770-66-1 1-{4-[2-(4-methylphenyl)ethynyl]phenyl}ethanone 
• 863098-32-2 1-(4-(bromoethynyl)phenyl)-ethan-1-one 
• 1086430-08-1 1-[4-(iodoethynyl)phenyl]ethanone 
• 1942-31-0 4-(phenylethinyl)acetophenone 
• 123770-67-2 1-(4-((4-methoxyphenyl)ethynyl)phenyl)ethanone 
• 1193111-07-7 (Z)-3-acetyl-4-(4-acetylphenyl)-2,4-pentadien-2-ol 
• 1401464-91-2 2-(1-(4-((trimethylsilyl)ethynyl)phenyl)ethylidene)malononitrile 
• 1401464-90-1 2-(4-ethynylphenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile 

Relevant academic research and scientific papers

Nickel-Catalyzed Decarbonylative Cycloaddition of Benzofuran-2,3-diones with Alkynes to Flavones

Using dppe as the ligand, the Nickel-catalyzed decarbonylative cycloaddition of benzofuran-2,3-diones with alkynes was established, and a variety of functional flavones were synthesized in 65–99% yields. Terminal alkynes with substituted phenyl groups and internal alkynes such as aryl acyl acetylenes and diphenylacetylenes are suitable for this reaction. The effects of bases on the reactions of different types of alkyne substrates were also investigated and discussed. (Figure presented.).

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

A practical strategy for construction and regulation of multi-functional triazepinium salts via highly efficient I2-catalyzed cyclization

Synthesis of new functional organic molecules is a critical path that may greatly accelerate the evolution of organic optoelectronic materials. We have achieved a facile synthesis strategy to produce unique saddle-shaped multi-functional triazepinium salt

Phenylglyoxal compound and hydrate, preparation method and application thereof

The invention provides a phenylglyoxal compound and a hydrate, a preparation method and application thereof, and belongs to the technical field of probe new materials, organic synthesis and fluorescence detection. The phenylglyoxal compound is shown as a

Aldol sensor-inspired fluorescent probes for measuring protein citrullination

Protein citrullination is an important posttranslational modification on an arginine residue. However, high quality fluorescent probes for measuring the citrullination level and capturing citrullinated proteins are quite limited. Inspired by the similarit

Gold-Catalyzed Functionalization of Semicarbazides with Terminal Alkynes to Achieve Substituted Semicarbazones

Gold-catalyzed functionalization of semicarbazides (ArNHCONHNH2) with various terminal alkynes R2C≡CH (R2 = Alk or Ar) in the presence of Ph3PAuNTf2 (3 mol-%) grants a range of substituted semicarbazo

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Sulfo-Phenylated Polyphenylenes Containing Sterically Hindered Pyridines

We systematically investigated the effect of incorporating a sterically hindered pyridyl group into a sulfo-phenylated polyphenylene to control the polymer's physicochemical properties through acid-base interactions. Homopolymers with similar molecular weights and comparable structures that vary by only one atom (N- vs C-) per repeat unit along the polymer chain were prepared. Compared to a non-pyridyl reference membrane, incorporation of a pyridyl group improves the oxidative stability against free radicals, increases the elongation at break to 55% (from 37%), and enhances the thermal stability to 326 °C (from 246 °C). In an accelerated fuel cell degradation test, polymeric membranes containing the sterically encumbered pyridyl unit exhibited exceptional stability (0.16 mV h-1 degradation rate over 1000 h) and retained ～80% of their peak power density over this time.