217495-91-5

Basic information

• Product Name: 4'-(4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-1-carbonyl)-2-phenylbenzanilide
• Synonyms: 4'-(4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-1-carbonyl)-2-phenylbenzanilide
• CAS NO: 217495-91-5
• Molecular Weight: 537.661
• Mol File: 217495-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-(4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-1-carbonyl)-2-phenylbenzanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-1-carbonyl)-2-phenylbenzanilide(217495-91-5)
• EPA Substance Registry System: 4'-(4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-1-carbonyl)-2-phenylbenzanilide(217495-91-5)

Safety Data

• Hazardous Substances Data: 217495-91-5(Hazardous Substances Data)

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 947-84-2 2-Biphenylcarboxylic acid 
• 217495-89-1 ethyl 4-([1,1'-biphenyl]-2-carboxamido)benzoate 
• 168626-74-2 4-[([1,1'-Biphenyl]-2-carbonyl)amino]benzoic Acid 
• 180340-05-0 4-[([1,1'-biphenyl]-2-carbonyl)amino]-benzoyl chloride 
• 40132-11-4 4-benzyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine 

Relevant articles and documents

Nonpeptide arginine vasopressin antagonists for both V(1A) and V2 receptors: Synthesis and pharmacological properties of 2-phenyl-4'-(2,3,4,5- tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide derivatives

A series of compounds structurally related to 2-phenyl-4'-(2,3,4,5- tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide was synthesized and demonstrated to have arginine vasopressin (AVP) antagonist activity for both V(1A) and V2 receptors. The introduction of a hydrophilic substituent group into the 5-position of the benzodiazepine ring resulted in an increase in oral availability. Especially, the (3-pyridyl)methyl (31b), the 2-(4- methyl)-1,4-diazepan-1-yl)-2-oxoethyl (32i), and the 2-(4-methylpiperazin-1- yl)ethyl (33g) derivatives exhibited high antagonist activities and high oral availability. Details of the synthesis and pharmacological properties of this series are presented.