21758-86-1

Usage

Uses

Used in Organic Synthesis:
1-(1-hydroxy-3,4-dioxo-3,4-dihydronaphthalen-2-yl)pyridinium is used as an intermediate in organic synthesis for its unique molecular structure, which can be further modified or utilized in the creation of other complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(1-hydroxy-3,4-dioxo-3,4-dihydronaphthalen-2-yl)pyridinium is used as a compound for research purposes. Its potential biological activity and chemical properties make it a candidate for the development of new drugs or drug candidates.
Used as a Reagent in Chemical Reactions:
Due to its distinct functional groups, 1-(1-hydroxy-3,4-dioxo-3,4-dihydronaphthalen-2-yl)pyridinium can be employed as a reagent in various chemical reactions, facilitating specific transformations or acting as a catalyst.
Further study and analysis of 1-(1-hydroxy-3,4-dioxo-3,4-dihydronaphthalen-2-yl)pyridinium's properties and potential applications are necessary to fully comprehend its significance in the field of chemistry.

Upstream product

• 110-86-1 pyridine 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 7605-25-6 ethyl phenylsulfenylacetate 
• 107-91-5 cyanoacetic acid amide 
• 480-41-1 naringenin 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 

Downstream Products

• 110-86-1 pyridine 
• 34014-51-2 1-hydroxy-isoquinoline-4-carboxylic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 528-46-1 phthalonic acid 
• 214-97-1 15,16-dithia-5,10-diazahexaphene 

Relevant academic research and scientific papers

Reaction of 2,3-dichloro-1,4-naphthoquinone with some active methylene compounds in different basic media

Reaction of 2,3-dichloro-1,4-naphthoquinone with some active methylene compounds, such as malononitrile and cyanoacetamide, under various basic conditions has been investigated. A mechanism for these reactions is proposed.

Synthesis of benzonaphthofuroquinones and benzoylnaphthindolizinediones by reactions of flavonoids with dichlone under basylous, oxygenous and aqueous conditions: Their cytotoxic and apoptotic activities

Using flavonoids and dichlone as substrates, benzonaphthofuroquinones (1, 2, 3, 5, 6, novel; 4 new) and benzoylnaphthindolizinediones (7, 8, known; 9, new) were synthesized through common base-catalyzed method and a new method of combining base-catalyzed with O2/H2O exposing. The possible reaction mechanisms may involve the process like isomerization, hydration, oxidation, decomposition and intermolecular condensation. Benzonaphthofuroquinones (2, 3, 4, 5) were found to exhibit potent cytotoxicity against carcinoma cell lines and low toxicity to normal cell lines. The compounds 4 and 5 not only expressed a significant late-stage-apoptosis against human leukemia and melanoma, but also promoted the cleavage of caspase-3 and PARP in human leukemia, which suggested that the late-stage-apoptosis and caspase-3 pathway may be responsible for the cytotoxicities of these benzonaphthofuroquinones. The replacement of the furan ring with pyrrole system in benzoylnaphthindolizinediones (7, 8, 9) resulted in the loss of anticancer activity.

Heterocyclic Quinonoid Chromophoric Systems : Part V - Synthesis of 3,4-Phthaloyl-2-thiaquinolizine

Condensation of α-mercaptomethylpyridine with 1,4-naphthoquinone, 2-chloro-1,4-naphthoquinone and 2,3-dichloro-1,4-naphthoquinone leads to a number of quinonoid derivatives including the desired 2-α-pyridylmethylmercapto-1,4-naphthoquinone (XVI) and its 3-chloro derivative (XI).Cyclization of XVI and XI gives 3,4-phthaloyl-2-thiaquinolizine (I) which represents a new heterocyclic quinonoid chromophoric system.Plausible mechanisms for the formation of the different heterocyclic quinones are discussed.Interaction of 1,4-naphthoquinone with 1-mercaptomethylisoquinoline affords 8,9-benzo-3,4-phthaloyl-2-thiaquinolizine (XXI).The thiaquinolizines undergo sulphur extrusion on heating to m.p. or on treatment with alkaline dithionite to yield the corresponding 2,3-phthaloylpyrrocolines.