217803-89-9

Usage

Uses

Used in Pharmaceutical Industry:
Cefpodoxime Proxetil IMpurity E is used as an impurity in the production of Cefotaxime for its antibiotic properties. It contributes to the overall effectiveness of the antibiotic by targeting a wide range of bacterial infections. The presence of this impurity is essential for the proper functioning and efficacy of Cefotaxime as a potent antibiotic agent.

Upstream product

• 98298-66-9 1-(isopropoxycarbonyloxy)ethyl chloride 
• 60846-23-3 cefotaxime sodium salt 
• 84089-73-6 1-iodoethyl isopropyl carbonate 
• 60846-21-1 (6R)-3-acetoxymethyl-7t-[2-(2-amino-thiazol-4-yl)-2-(Z)-methoxyimino-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

Preparation of Ceph-3-em esters unaccompanied by Δ3 to Δ2 isomerization of the cephalosporin derivatives

A synthesis of cephalosporin derivatives by reacting cephalosporin free carboxylic acid with alkyl halide in the presence of cesium carbonate and potassium carbonate is disclosed. Δ3 to Δ2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives, was successfully eliminated. The desired Δ3 was obtained as a sloe product in the reaction.

An effective and convenient esterification of cephalosporin derivatives by using quarternary ammonium salts as catalysts

A method for preparing cephalosporin derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quarternary ammonium salts catalyst is disclosed. Δ3 to Δ2 isomerization, a side reaction commonly