Preparation of Ceph-3-em esters unaccompanied by Δ3 to Δ2 isomerization of the cephalosporin derivatives

Article abstract of DOI:10.1080/00397919908086176

A synthesis of cephalosporin derivatives by reacting cephalosporin free carboxylic acid with alkyl halide in the presence of cesium carbonate and potassium carbonate is disclosed. Δ³ to Δ² isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives, was successfully eliminated. The desired Δ³ was obtained as a sloe product in the reaction.

Full text of DOI:10.1080/00397919908086176

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Synthetic Communications: An
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Organic Chemistry
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Preparation Of Ceph-3-Em
Esters Unaccompanied By δ3
To δ2 Isomerization Of The
Cephalosporin Derivatives
Hong Woo Lee a , Tae Won Kang a , Eung Nam Kim a ,
Kyung Hoi Cha a , Jaewook Shin a , Dong Ock Cho a ,
Nam Hee Choi a , Jung Woo Kim a & Chung Hong II a
a Research Institute, Chong Kun Dang Corp. , CPO
Box 3477, Seoul, 152-600, Korea
Published online: 17 Sep 2007.
To cite this article: Hong Woo Lee , Tae Won Kang , Eung Nam Kim , Kyung Hoi Cha ,
Jaewook Shin , Dong Ock Cho , Nam Hee Choi , Jung Woo Kim & Chung Hong II (1999)
Preparation Of Ceph-3-Em Esters Unaccompanied By δ3 To δ2 Isomerization Of The
Cephalosporin Derivatives, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 29:11, 1873-1887, DOI:
10.1080/00397919908086176
To link to this article: http://dx.doi.org/10.1080/00397919908086176
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