21794-93-4

Upstream product

• 113-98-4 Penicillin G potassium 
• 62-55-5 thioacetamide 
• 594-42-3 chlorothio-trichloro-methane 
• 75-78-5 dimethylsilicon dichloride 
• 40273-68-5 rac-6β-tritylamino-penicillanic acid benzyl ester 
• 97656-36-5 (4S)-2t-((R)-carboxy-tritylamino-methyl)-5,5-dimethyl-thiazolidine-4r-carboxylic acid benzyl ester 
• 496809-25-7 benzylpenicillin 
• 40124-92-3 rac-6β-tritylamino-penicillanic acid 
• 61-33-6 penicillin G 

Downstream Products

• 205320-24-7 6,6-dibromopenicillanic acid 
• 47294-44-0 6α-(2-phenyl-acetylamino)-penicillanic acid 
• 14689-79-3 6β-(2-hydroxy-benzylideneamino)-penicillanic acid 
• 87417-35-4 5-[(1R,5R)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-allyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87417-35-4 (S)-5-[(1S,5S)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-allyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87408-06-8 5-[(1R,5R)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-propyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87408-06-8 (S)-5-[(1S,5S)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-propyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87408-05-7 (2S,5R,6R)-6-(5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-pentanoylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 87408-05-7 iso-penicillin N 
• 87417-34-3 (2S,5R,6R)-6-(5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-pentanoylamino)-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 87417-34-3 benzhydryl N-δ--6-aminopenicillanate β-sulfoxide 
• 47547-28-4 6-aminopenicillanic acid diphenylmethyl ester 
• 24138-28-1 6-bromopenicillanic acid 
• 24158-88-1 6,6-dibromopenicillanic acid 

Relevant academic research and scientific papers

Enzymatic hydrolysis of β-lactam antibiotics at low pH in a two-phase "aqueous solution - Water-immiscible organic solvent" system

The application of the two-phase "aqueous solution - water-immiscible organic solvent" system is suggested not for effective biocatalytic synthesis, but for hydrolytic purposes. Enzymatic hydrolysis of benzylpenicillin and N-phenylacetamidodesacetoxycepha

Deacylation of amides

De-acylation of Penicillins and Cephalosporins to obtain the corresponding 6-aminopenicillanic acid or 7-aminocephalosporanic acid by the imino halide/imino ether process using long chain bases.

β-Lactam antibiotic esterification process using methoxymethyl methane sulfonate

Disclosed is an improved process for esterifying carboxylic acids, particularly 3-carboxylic acid groups of penicillins and 4-carboxylic acid groups of cephalosporins, to form methoxymethyl esters. Replacement according to the present process of the conventional halomethyl methyl ether esterifying agent with methoxymethyl mesylate avoids the carcinogenicity problem of the prior art reagent while still giving good yields of high quality product.

Process for production of 6-aminopenicillanic acid or 7-aminocephalosporanic acid derivatives

A derivative of 6-aminopenicillanic acid or 7-aminocephalosporanic acid is produced by a process which comprises chlorinating or brominating a 6-thioacylaminopenicillanic acid or 7-thioacylaminocephalosporanic acid compound to obtain a corresponding iminothiohalide compound, and then solvolyzing the iminothiohalide compound. The process is novel and industrially feasible for producing the amino compound, which is not accompanied by "reconversion reaction".

Process for producing 6-aminopenicillanic acid or 7-aminocephalosporanic acid derivatives

A derivative of 6-aminopenicillanic acid or 7-aminocephalosporanic acid is produced by a process which comprises disulfidizing a 6-thioacylaminopenicillanic acid or 7-thioacylaminocephalosporanic acid compound to obtain a corresponding disulfide compound, and then solvolyzing the disulfide compound. The process is novel and industrially feasible for producing the amino compound, which is not accompanied by "reconversion reaction".

Novel penicillins and cephalosporins and process for producing the same

Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.

Immobilized microbial cells

Immobilized microbial cells are prepared by treating microbial cells with a polyfunctional cross-linking reagent and contacting the treated cells in aqueous medium with a water insoluble particulate polymer prepared by polymerizing an ethylenically unsaturated monomer. Alternatively, the treated cells may be bonded to the monomer prior to polymerizing.

Process for the manufacture of aminoazetidinones

The present invention relates to a new process for the preparation of 6-aminopenicillanic acid and 7-amino-cephalosporanic acid derivatives by treating the corresponding acylamino derivatives with phosphinic acid chlorides, reacting the mixed acid anhydrides so obtained with agents forming imidohalides, converting the imido halides into iminoethers and hydrolysing them.

1-Oxides of Schiff bases of 6-aminopenicillanic acid

Compounds containing a cephem nucleus are prepared by heating a 1-oxide of a Schiff base of 6-aminopenicillanic acid. These cephem compounds are useful as intermediates in the preparation of physiologically active cephalosporins.