47294-44-0

Upstream product

• 21794-93-4 6-aminopenicillanic acid 
• 98-88-4 benzoyl chloride 
• 18715-92-9 6α-((R)-2,2-dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-penicillanic acid 
• 80127-23-7 penicillin G allyl ester 

Downstream Products

• 13057-98-2 benzylpenicilloic acid 
• 3264-88-8 benzylpenicillenic acid 
• 13093-87-3 benzylpenicillic acid 
• 21794-95-6 6α-(2-phenyl-acetylamino)-penicillanic acid methyl ester 

Relevant academic research and scientific papers

MILD PALLADIUM(0)-CATALYZED DEPROTECTION OF ALLYL ESTERS. A USEFUL APPLICATION IN THE SYNTHESIS OF CARBAPENEMS AND OTHER β-LACTAM DERIVATIVES.

Carbapenem and other β-lactam allyl ester derivatives are efficiently deprotected with pyrrolidine in the presence of catalytic amount of Pd(0).

6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

6-beta-Halopenicillanic acid 1,1-dioxides, physiologically acceptable salts thereof and esters thereof readily hydrolyzable; pharmaceutical compositions containing a 6-beta-halopenicillanic acid 1,1-dioxide, a physiologically acceptable salt thereof or an ester thereof readily hydrolyzable; and a method for enhancing the effectiveness of a beta-lactam antibiotic, using a 6-beta-halopenicillanic acid 1,1-dioxide, a physiologically acceptable salt thereof or an ester thereof readily hydrolyzable.

ACETOXYMETHYL PENAM COMPOUNDS AS BETA-LACTAMASE INHIBITORS

2-beta-Acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide, pharmaceutically-acceptable salts thereof and esters thereof readily hydrolyzable in vivo; pharmaceutical compositions containing 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide or salt or ester thereof; and method of enhancing the effectiveness of a beta-lactam antibiotic using 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide or salt or ester thereof

Method for increasing antibacterial effectiveness of a β-lactam antibiotic

6-Aminopenicillanic acid 1,1-dioxide, esters thereof readily hydrolyzable in vivo, and the pharmaceutically-acceptable salts of these compounds, are useful for enhancing the effectiveness of certain β-lactam antibiotics against certain β-lactamase producing bacteria. Derivatives of 6-aminopenicillanic acid 1,1-dioxide protected by a conventional carboxy protecting group are useful intermediates to 6-aminopenicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo.

DERIVATIVES OF 6BETA-HYDROXYALKYLPENICILLANIC ACIDS AS BETA-LACTAMASE INHIBITORS

6beta-Hydroxyalkylpenicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several beta-lactam antibiotics against many beta-lactamase producing bacteria, and 6beta-substituted penicillanic acid benzyl ester derivatives as useful intermediates leading to said agents which enhance the effectiveness of beta-lactam antibiotics

Penam 1,1-dioxides as beta-lactamase inhibitors

(3S, 5R)-Penam-3-carboxylic acid 1,1-dioxide, optionally having a methyl group at the 2-position, and esters thereof readily hydrolyzable in vivo, are useful for enhancing the effectiveness of several beta-lactam antibiotics against many beta-lactamase producing bacteria.