218300-35-7Relevant academic research and scientific papers
Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain
Schoepfer, Joseph,Gay, Brigitte,Caravatti, Giorgio,Garcia-Echeverria, Carlos,Fretz, Heinz,Rahuel, Joseph,Furet, Pascal
, p. 2865 - 2870 (1998)
We have designed and synthesized a (3-aminomethyl-phenyl)-urea scaffold to mimic the X+1-Asn part of the minimal phosphopeptide sequence, Ac-pTyr- X+1-Asn-NH2, recognized by the Grb2SH2 domain. The resulting compounds show the same d
