Bioorganic and Medicinal Chemistry Letters p. 2865 - 2870 (1998)
Update date:2022-07-29
Topics:
Schoepfer, Joseph
Gay, Brigitte
Caravatti, Giorgio
Garcia-Echeverria, Carlos
Fretz, Heinz
Rahuel, Joseph
Furet, Pascal
We have designed and synthesized a (3-aminomethyl-phenyl)-urea scaffold to mimic the X+1-Asn part of the minimal phosphopeptide sequence, Ac-pTyr- X+1-Asn-NH2, recognized by the Grb2SH2 domain. The resulting compounds show the same d
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