Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain

DOI: 10.1016/S0960-894X(98)00513-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2865 - 2870 (1998)

Update date:2022-07-29

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Authors:

Schoepfer, Joseph

Gay, Brigitte

Caravatti, Giorgio

Garcia-Echeverria, Carlos

Fretz, Heinz

Rahuel, Joseph

Furet, Pascal

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Article abstract of DOI:10.1016/S0960-894X(98)00513-7

We have designed and synthesized a (3-aminomethyl-phenyl)-urea scaffold to mimic the X₊₁-Asn part of the minimal phosphopeptide sequence, Ac-pTyr- X₊₁-Asn-NH2, recognized by the Grb2SH2 domain. The resulting compounds show the same d

Full text of DOI:10.1016/S0960-894X(98)00513-7

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