6-chloro-7-fluoro-2,3-diphenylquinoxaline

Base Information

• Chemical Name: 6-chloro-7-fluoro-2,3-diphenylquinoxaline
• CAS No.: 218456-76-9
• Molecular Formula: C20H12ClFN2
• Molecular Weight: 334.78
• Mol file: 218456-76-9.mol

Synonyms:6-chloro-7-fluoro-2,3-diphenylquinoxaline

Chemical Property of 6-chloro-7-fluoro-2,3-diphenylquinoxaline

Chemical Property:

• PSA: 25.78000
• LogP: 5.75630
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

6-Chloro-7-fluoro-2,3-diphenylquinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-7-fluoro-2,3-diphenylquinoxaline

There total 6 articles about 6-chloro-7-fluoro-2,3-diphenylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzil (134-81-6) + 4-chloro-5-fluorobenzene-1,2-diamine (139512-70-2) → 6-chloro-7-fluoro-2, 3-diphenylquinoxaline (218456-76-9)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 20 ℃; for 5h;

DOI:10.1039/c6ra03078e

Reference yield: 76.0%

phenyl benzyl ketone (451-40-1) + 4-chloro-5-fluorobenzene-1,2-diamine (139512-70-2) → 6-chloro-7-fluoro-2, 3-diphenylquinoxaline (218456-76-9)

Guidance literature:

With oxygen; triethylamine; In toluene; at 90 ℃; for 12h; under 760.051 Torr;

DOI:10.1016/j.tet.2012.03.020

Reference yield:

N-(3-chloro-4-fluoro-2-nitrophenyl)acetamide (81962-58-5) → 6-chloro-7-fluoro-2, 3-diphenylquinoxaline (218456-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 0.25 h / 100 °C

2: zinc; hydrazinium monoformate / methanol / 20 °C / Inert atmosphere

3: acetic acid / 2.5 h / Reflux

With sulfuric acid; acetic acid; zinc; hydrazinium monoformate; In methanol;

DOI:10.1016/j.ejmech.2016.04.019

upstream raw materials:

phenyl benzyl ketone

4-chloro-5-fluorobenzene-1,2-diamine

benzil

N-(3-chloro-4-fluorophenyl)acetamide

Refernces

• 1、 Patel, Saloni B.,Patel, Bhumika D.,Pannecouque, Christophe,Bhatt, Hardik G.. "Design, synthesis and anti-HIV activity of novel quinoxaline derivatives". . p. 230 - 240. Retrieved 2016/04/26.