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• 108-94-1 cyclohexanone 
• 100-52-7 benzaldehyde 
• 106-40-1 4-bromo-aniline 

Relevant academic research and scientific papers

Synthesis of β-amino carbonyl compounds via a Zn(OTf)2-catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds

A Zn(OTf)2-catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds was described. This one-pot three-component reaction afforded the corresponding β-amino carbonyl compounds, β-amino esters, and β-amino ketones in good to excellent yields. The reaction was also applied for the liquid-phase synthesis of β-amino carbonyl compound library using PEG as a support.

H3PW12O40 anchored on graphene-grafted silica-coated MnFe2O4 as magnetic catalyst for Mannich reaction

In this study, a three-component nanocomposite consisted of graphene, manganese ferrite and phosphotungstic acid (PTA) has been prepared. This composite, which is designated as Graphene/MnFe2O4@PTA, was synthesized through anchoring of PTA–imidazolium ionic liquid on magnetic graphene sheets. The structural and magnetic properties of the fabricated nanocomposite were studied by employing FT-IR, SEM, EDX, TEM, ICP, VSM, P-XRD and BET techniques. The synthesized magnetic nanocomposite was examined as an efficient and recyclable acidic catalyst for Mannich reaction under solvent-free conditions. The products of this reaction, which are an important class of potentially bioactive compounds, were obtained with good to excellent yields, and the catalyst could be readily recycled without any significant loss of its activity.

One-pot, three-component Mannich-type reaction catalyzed by functionalized ionic liquid

A three-component Mannich-type reaction of aromatic aldehydes, aromatic amines, and ketones was catalyzed by a novel functionalized ionic liquid, 3-(N,N-dimethyldodecylammonium)propanesulfonic acid hydrogen sulfate ([DDPA][HSO4]) at room temperature to give various β-amino carbonyl compounds in good yields. The catalyst could be reused at least six times without noticeably reducing catalytic activity.

Basic functionalized ionic liquid catalyzed One-pot mannich-type reaction: Three component synthesis of β-Amino carbonyl compounds

Three-component Mannich-type reaction of cyclohexanone, aromatic aldehydes, and aromatic amines was catalyzed by a basic functionalized ionic liquid, 1-butyl-3-methylimidazolium hydroxide ([bmim][OH]), at room temperature to give various β-amino carbonyl compounds in high yields. The ionic liquid, which is environmentally friendly, can be recycled at least 5 times without significant loss of activity.

HClO4-SiO2 catalyzed stereoselective synthesis of β-amino ketones via a direct Mannich-type reaction

The HClO4-SiO2 catalyzed three-component, one-pot Mannich reaction of ketones, aromatic aldehydes and aromatic amines is carried out in ethanol to afford the corresponding β-amino ketones in good yields and high stereoselectivities in favor of the anti-isomer. Three new compounds are reported.