1190991-72-0

Upstream product

• 5957-90-4 4-(2-pyridinyl)anisole 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 21864-90-4 N-(tert-butyl)benzimidoyl cyanide 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 7321-55-3 2,2-dimethylmalononitrile 
• 109-04-6 2-bromo-pyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 67-68-5 dimethyl sulfoxide 
• 135205-66-2 N?cyanosuccinimide 
• 75-05-8 acetonitrile 
• 140-29-4 phenylacetonitrile 

Relevant academic research and scientific papers

Rhodium(iii)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent

A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and commercially available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction.

Preparation method for aromatic nitrile compound

The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry, and provides a preparation method for an aromatic nitrile compound. Under the effect ofa metal catalyzer and additives, dimethylmalononitrile as a material reacts with a 2-phenylpyridine compound in an anhydrous organic solvent, so that the aromatic nitrile compound is obtained. The preparation method has the advantages of easiness in operation, mild conditions, environment-friendliness and possibility in realizing industrialization, and moreover, the aromatic nitrile compound canbe obtained at high yield; and the aromatic nitrile compound which is synthesized by utilizing the method can be further functionalized to obtain various compounds, and can be applied in the development and research of natural products, functional materials and fine chemicals.

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids

A Cp?Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups.

Copper-mediated C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.

Synthetic method of arylnitrile compounds

The invention belongs to the technical field of synthesis of medical and chemical engineering intermediates, and provides a synthetic method of arylnitrile compounds. A series of the arylnitrile compounds are synthesized through a heating reaction of a 2-phenylpyridine derivative and N-cyan-N-p-methoxyphenyl-p-benzenesulfonamide in a solvent with a manganese salt as a catalyst. The arylnitrile compounds are an important composition part of many drugs and bioactive molecules, have important applications in the fields of organic synthesis and medicinal chemistry, and have a broad market prospect. The method has the advantages of simple steps, easily obtained raw materials, mild reaction conditions, great use values and great social and economic benefits.

α-Iminonitrile: A new cyanating agent for the palladium catalyzed C-H cyanation of arenes

An efficient palladium-catalyzed C-H cyanation reaction of arenes using α-iminonitrile as a new cyanating reagent has been developed. With high regioselectivity and broad substrate scope, this reaction offers monocyanated products in moderate to excellent

A Pd(ii)/Mg-La mixed oxide catalyst for cyanation of aryl C-H bonds and tandem Suzuki-cyanation reactions

A palladium(ii)/magnesium-lanthanum mixed oxide (Pd(ii)/Mg-La) catalyst is a reusable catalyst for cyanation of aromatic C-H bonds by using the combination of NH4HCO3 and DMSO as the ''CN'' source. Moderate to good yields of aromatic nitriles were obtained. An excellent regioselectivity was achieved using the present protocol. A tandem process involving Suzuki coupling followed by a cyanation reaction was also developed using the heterogeneous (Pd(ii)/Mg-La) catalyst. This cascade process resulted in the formation of aromatic nitrile from simple 2-halopyridine. The catalyst was recovered by centrifugation and reused for three consecutive cycles with nearly consistent activity and selectivity. This journal is

Cobalt-catalyzed C-H cyanation of (Hetero)arenes and 6-Arylpurines with N -cyanosuccinimide as a new cyanating agent

A cobalt-catalyzed C-H cyanation reaction of arenes has been developed using N-cyanosuccinimide as a new electrophilic cyanating agent. The reaction proceeds with high selectivity to afford monocyanated products with excellent functional group tolerance. Substrate scope was found to be broad enough to include a wide range of heterocycles including 6-arylpurines.

Cobalt-catalyzed C-H cyanation of arenes and heteroarenes

Carboxylate assistance proved to be the key for the success of efficient cobalt(III)-catalyzed C-H cyanations. Thus, an in situ generated cationic cobalt complex was identified as a versatile catalyst for the site-selective synthesis of various aromatic a

Co(III)-catalyzed C-H activation/formal SN-type reactions: Selective and efficient cyanation, halogenation, and allylation

The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal SN-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in CpCo(III)-catalyzed C-H activation for the first time.