21886-60-2

Basic information

• Product Name: 2-chloro-4-isopropylacetophenone
• Synonyms: 2-chloro-4-isopropylacetophenone;Ethanone,2-chloro-1-[4-(1-Methylethyl)phenyl]-
• CAS NO: 21886-60-2
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.676
• Mol File: 21886-60-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 297.1 °C at 760 mmHg
• Flash Point: 159.5 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.00137mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 2-chloro-4-isopropylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-isopropylacetophenone(21886-60-2)
• EPA Substance Registry System: 2-chloro-4-isopropylacetophenone(21886-60-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 21886-60-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-isopropylacetophenone is a chemical compound with the molecular formula C10H11ClO. It is a white to off-white crystalline solid with a slightly aromatic odor. 2-chloro-4-isopropylacetophenone is widely used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical products. It is also used as a raw material for the synthesis of insecticides and herbicides. Additionally, 2-chloro-4-isopropylacetophenone is used as a reagent in organic chemical reactions, making it an important compound in organic synthesis. Its structure and properties make it a valuable and versatile chemical in various industrial applications.

InChI:InChI=1/C11H13ClO/c1-8(2)9-3-5-10(6-4-9)11(13)7-12/h3-6,8H,7H2,1-2H3

Upstream product

• 2055-40-5 4-isopropylstyrene 
• 98-82-8 Isopropylbenzene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 619-76-1 4-isopropylbenzamide 
• 91244-27-8 4-isopropyl-phenethyl chloride 
• 176646-88-1 1-(p-isopropylphenyl)-1,2-ethanadiol 
• 176646-89-2 1-(p-isopropylphenyl)-2-chloroethanol 

Relevant articles and documents

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

Deacetalization by photoinduced electron transfer with a pyrylium salt: Effect of limiting the amounts of water, oxygen and sensitizer

The photodeacetalization of 4-(p-isopropylphenyl)-2-nonyl-1,3-dioxolane 1 using 2,4,6-triphenylpyrylium tetrafluoroborate (TPT) as sensitizer has been studied to explore the possibility of achieving a slow sunlight-controlled release of polymer-bound carbonyl functionalized semiochemicals. This reaction has been found to produce mainly n-decanal and p-isopropylbenzaldehyde, together with lower amounts of the corresponding acids. The degree of conversion and the product distribution depended on the presence of water or oxygen and the amount of photosensitizer. The results are justified through generation of the radical cation 1+., followed by ring opening and trapping of the radical/cationic sites by oxygen or water. The delocalized 1,3-radical cations III and the ozonides IV appear to be involved as key intermediates. Formation of n-nonanal as a minor product is explained through cleavage of the C2-nonyl bond of 1+..