21923-43-3

Upstream product

• 99-90-1 para-bromoacetophenone 
• 719-64-2 5-chloro-3-phenylanthranil 
• 1159372-20-9 (2-amino-5-chlorophenyl)(phenyl)methanol 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 59862-55-4 p-bromoacetophenone oxime 

Relevant academic research and scientific papers

Synthesis and trypanocidal activity of substituted 2,4-diarylquinoline derivatives

A small library of nine, novel 2,4-diarylquinoline derivatives has been prepared in high yield via convenient one-or two-step routes from a series of substituted 2-Aminobenzophenones. None of the products exhibited toxicity at 20 uM against human cervix a

Catalyst free indirect Friedlaender synthesis of substituted quinolines from alcohols in PEG-400

The synthesis of substituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding aminoalcohol and ketone using PEG-400 as reaction medium in the presence of a base, without any transition-metal catalyst.

Dowex-50w promoted friedlaender synthesis of substituted quinolines under solvent-free conditions

An efficient method for the synthesis of substituted quinolines using Dowex-50W ion exchange resin as reusable eco-friendly catalyst vai Friedlaender annulation under solvent-free conditions is described. The Japan Institute of Heterocyclic Chemistry.

Green approach for the efficient synthesis of quinolines promoted by citric acid

Citric acid promoted Friedlander synthesis of a mini-library of poly substituted quinolines (30 examples) at 100 °C under solvent-free conditions was achieved in moderate to excellent yields (54-99%). The method is simple, cost-effective and environmental

Preparation of 2-arninpbenzophenones and polysubstituted quinolines through Sml2 promoted reductive cleavage of 3-aryl-2,1-benzisoxazoles

Promoted by SmI2, 3-aryl-2,1-benzisoxazoles underwent reductive cleavage of the N - O bond leading to 2-aminobenzophenones in high yields upon protonation. Otherwise, if ketones with active methylene group were added to the reaction mixture prior to protonation, the desired poly substituted quinolines could be obtained under mild conditions in a one-pot manner.

Green preparation of quinoline derivatives through FeCl3· 6H2O Friedlander reaction in ionic liquids

The preparation of substituted quinoline derivatives through a Friedlander condensation reaction utilizing the ionic liquid [bmim][BF4] as the reaction medium and iron chloride hexahydrate (FeCl3·6H 2O) as a catalyst is de

A novel preparation of 4-phenylquinoline derivatives in ionic liquids

A novel preparation of 4-phenylquinoline derivatives through acid-catalyzed Friedlaender reaction in ionic liquid ([bmim][BF4]) is described. The preparative procedure presented in this paper is operationally simple and environmentally benign.

Ionic Liquid-Promoted Regiospecific Friedlander Annulation: Novel Synthesis of Quinolines and Fused Polycyclic Quinolines

Several room-temperature ionic liquids (ILs) based on 1-butylimidazolium salts with varying anions were synthesized and evaluated for the preparation of biologically active substituted quinolines and fused polycyclic quinolines using the Friedlander heter

SmI2-mediated facile one-pot preparation of 2,4-diarylquinolines from 3-aryl-2,1-benzisoxazoles

On treatment with SmI2, 3-aryl-2,1-benzisoxazoles undergo reductive cleavage of the N-O bond leading to 2-aminobenzophenones in high yields upon protonation. If aryl methyl ketones are added to the reaction mixture prior to protonation, the desired 2,4-diarylquinolines can be obtained in moderate yields under mild conditions.

Preparation of 2,4-Diarylquinolines and Substituted Dihydrobenzacridines by the Condensation of Certain C(α),O-Dilithiooximes with 2-Aminobenzophenones

C(α),O-Dilithiooximes were prepared in an excess of lithium diisopropylamide and condensed with several 2-aminobenzophenones, followed by acid hydrolysis of the oximes to the ketones, which then underwent cyclodehydration to give substituted quinolines or dihydrobenzacridines.