21939-23-1Relevant academic research and scientific papers
Reactivity and Diastereoselectivity of Grignard Reagents towards the Hydrazone Functionality in Toluene Solvent
Alexakis, Alex,Lensen, Nathalie,Tranchier, Jean-Philippe,Mangeney, Pierre
, p. 4563 - 4565 (2007/10/02)
Grignard reagents, in toluene solvent, display a strongly increased reactivity toward the hydrazone functionality.With the chiral synthon 1, a highly diastereoselective addition occurs, through chelation control, whereas with pyrazolines 4 and 9 only the d,l diastereomer is formed, leading to a very short synthesis of 1,3-diphenyl-1,3-diaminopropane (11).
Reaction of Aldehydes with Hydrazine Hydrochlorides in the Presence of Dipolarophiles; Intra- and Intermolecular + + 2> Cycloadditions
Shimizu, Tomio,Hayashi, Yoshiyuki,Miki, Masayuki,Teramura, Kazuhiro
, p. 2277 - 2285 (2007/10/02)
The reaction of 2 molar equiv of several 2-(alkenyloxy)-1-naphthaldehydes (2) with hydrazine dihydrochloride (3) and subsequent treatment of the mixture with triethylamine lead to intramolecular + + 2> criss-cross cycloadducts 5, 2:1 molar pr
