Design, synthesis and biological activity of a pyrrolo [2, 1- c][1,4]benzodiazepine (PBD)-distamycin hybrid

DOI: 10.1016/S0960-894X(98)00544-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3019 - 3024 (1998)

Update date:2022-07-30

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Authors:

Baraldi, Pier Giovanni

Cacciari, Barbara

Guiotto, Andrea

Leoni, Alberto

Romagnoli, Romeo

Spalluto, Giampiero

Mongelli, Nicola

Howard, Philip W.

Thurston, David E.

Bianchi, Nicoletta

Gambari, Roberto

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Article abstract of DOI:10.1016/S0960-894X(98)00544-7

We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1- c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybr

Full text of DOI:10.1016/S0960-894X(98)00544-7

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