219606-57-2Relevant academic research and scientific papers
Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes
Liu, Teng,Tian, Lixia,Lai, Junshan,Min, Deng,Qu, Mengnan,Tang, Shouchu
supporting information, p. 4068 - 4071 (2017/07/10)
An alcohol-mediated dithioacetalization process that gains direct access to the corresponding Markovnikov-selective 1,3-dithianes using unactivated alkynes and nonthiolic/odorless 2-chloro-1,3-dithiane in a highly efficient manner has been developed. This methodology has the advantage of having mild reaction conditions, and the dithioacetalization process gives good to excellent yields with high Markovnikov-selectivity.
Intramolecularly sulfur-stabilized silicon cations as Lewis acid catalysts
Rohde, Volker H. G.,Pommerening, Phillip,Klare, Hendrik F. T.,Oestreich, Martin
, p. 3618 - 3628 (2014/08/05)
The synthesis and spectroscopic characterization of previously unprecedented sulfur-stabilized silicon cations are reported. Several 1,3-dithiolan-2-yl- and 1,3-dithian-2-yl-substituted silanes were prepared and successfully transformed into the corresponding silicon cations by hydride abstraction. The silicon-sulfur interaction creates three consecutive stereocenters at three different elements. It is remarkable that the present stereocenter at the silicon atom determines the stereochemical outcome at the formerly prochiral sulfur and carbon atoms with excellent diastereoselectivity. All sulfur-stabilized silicon cations are shown to be potent catalysts in a challenging Diels-Alder reaction. Moreover, structurally related oxazoline-stabilized silicon cations were generated and characterized but found to be unreactive.
Sulfur as a bridge: Synthesis of medium rings via a bicyclic sulfonium ion
Zhou, Hongwei,Xing, Yanpeng,Liu, Le,Hong, Junjie
scheme or table, p. 3146 - 3150 (2012/01/02)
A facile and efficient synthesis of medium rings via a bicyclic sulfonium ion was developed. Spectroscopic evidence for the formation of an intermediate sulfonium moiety is provided. The sulfur atom served as a "bridge" to access the medium ring system and could be removed after use via a Ramberg-Baecklund process. As a result of the readily available starting materials, simple operation, and mild conditions, these reactions should be an appealing strategy in organic synthesis. Copyright
2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: Small molecule non-peptide antagonists of the human galanin hGAL-1 receptor
Scott, Malcolm K.,Ross, Tina M.,Lee, Daniel H. S.,Wang, Hoau-Yan,Shank, Richard P.,Wild, Kenneth D.,Davis, Coralie B.,Crooke, Jeffrey J.,Potocki, Alexander C.,Reitz, Allen B.
, p. 1383 - 1391 (2007/10/03)
The neuropeptide galanin modulates several physiological functions such as cognition, learning, feeding behavior, and depression, probably via the galanin 1 receptor (GAL-R1). Using an HTS assay based on 125I-human galanin binding to the human
