21968-26-3

Basic information

• Product Name: N-FORMYL-4-PIPECOLINE
• Synonyms: N-FORMYL-4-PIPECOLINE;1-Piperidinecarboxaldehyde, 4-methyl-
• CAS NO: 21968-26-3
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 21968-26-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-FORMYL-4-PIPECOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-FORMYL-4-PIPECOLINE(21968-26-3)
• EPA Substance Registry System: N-FORMYL-4-PIPECOLINE(21968-26-3)

Safety Data

• Hazardous Substances Data: 21968-26-3(Hazardous Substances Data)

Upstream product

• 626-58-4 4-methylpiperidin 
• 75-87-6 chloral 
• 124-38-9 carbon dioxide 
• 50-00-0 formaldehyd 
• 56-81-5 glycerol 
• 96-26-4 dihydroxyacetone 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 
• 108-89-4 picoline 
• 201230-82-2 carbon monoxide 
• 18513-84-3 4-methyl-1-(2-methyl-propenyl)-piperidine 
• 73822-92-1 1,2-bis(4-methylpiperidin-1-yl)ethane 
• 67-66-3 chloroform 

Downstream Products

• 637751-97-4 3-(2,3-dihydrobenzo[1,4]dioxan-6-yl)-7-hydroxy-8-(4-methylpiperidin-1-ylmethyl)-chromen-4-one 

Relevant articles and documents

Thioamides and selenoamides with chirality solely due to hindered rotation about the C-N bond: Enantioselective complexation with optically active hosts

Several thioformamides and selenoformamides, with chirality solely due to restricted rotation about the C-N bond, were resolved to enantiomers by inclusion crystallization with optically active diols (TADDOLs). The absolute configuration of the guest molecules was deduced from the X-ray crystal structures of the inclusion complexes. The optical activity of the resolved compounds is manifested by their CD spectra showing relatively strong Cotton effects in the region of thioamide or selenoamide n-π* transition. The optically active thioformamides and selenoformamides are configurationally labile compounds and gradually racemize in solution but are stable in the form of the inclusion complexes. The first-order kinetics of the racemization in solution allowed us to assign the C-N rotation barriers of thioformamides by spectropolarimetric measurements.

The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles

A mild and efficient method for the synthesis of cyanoformamides from N,N-disubstituted aminomalononitriles with CsF as the promoter has been developed. This method features a wide substrate scope and high reaction efficiency, and will facilitate corresponding cyanoformamide-based biological studies and synthetic methodology development.

Method for preparing N-formylated amine compounds

The invention discloses a method for preparation N-formylated amine compounds. In the method, the amine compounds and 1,3-dihydroxy acetone are taken as reaction raw materials reacting in a reactor for 2-48 hours at the reaction temperature of 0-100DEG C in a reaction medium in the presence of composite catalysts and oxidants, and the N-formylated amine compounds are obtained. The method is simpleand moderate in reaction conditions, cost can be reduced, target products can be obtained with high yield, and the catalysts used have high catalytic activity and are easy to be separated from a reaction system and reuses; the method is environment friendly during the whole process, the reaction raw materials are easy to be converted from biodiesel by-product propylene glycol, and use of glycerolis facilitated.