21983-80-2Relevant academic research and scientific papers
Preparation method of epoxiconazole intermediate
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Paragraph 0029; 0035; 0036, (2020/07/24)
The invention relates to a preparation method of an epoxiconazole intermediate, which comprises the following steps of reacting a raw material A with a raw material B, and carrying out acidolysis to obtain the epoxiconazole intermediate. The raw material A is as described in the specification, the raw material B is one or several selected from what is described in the specification, and the epoxiconazole intermediate is as described in the specification. The preparation process is relatively simple, easily available in raw materials, low in cost, fewer in three wastes, relatively high in target product content and yield, stable in process and suitable for industrial production.
Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Piperazin-2-ones
Wang, Yanzhao,Liu, Yuanyuan,Li, Kun,Yang, Guoqiang,Zhang, Wanbin
supporting information, p. 1933 - 1941 (2017/06/09)
Two different iridium catalyst systems, generated from the ruthenocene-based phosphine-oxazoline ligand tBu-mono-RuPHOX or the diphosphine ligand BINAP, were developed for the asymmetric hydrogenation of 5,6-dihydropyrazin-2(1H)-ones, affording chiral piperazin-2-ones in good yields and with moderate to good ees. Different catalytic behaviors for the hydrogenation of these types of substrate were observed with these two catalyst systems. Our tBu-mono-RuPHOX ligand, which bears a ruthenocene scaffold with planar chirality, was found to be the best ligand for the [Ir(L)(COD)]BArF catalyst system, affording the desired products with up to 94% ee. (Figure presented.).
Efficient preparation of α-ketoacetals
Ayala-Mata, Francisco,Barrera-Mendoza, Citlalli,Jimenez-Vazquez, Hugo A.,Vargas-Diaz, Elena,Zepeda, L. Gerardo
, p. 13864 - 13878 (2013/03/13)
The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
Synthesis of Four 14C-Isotopomers of Epoxiconazole, a New Triazole Fungicide
Burger, Tycho,Karbach, Stefan,Niemeyer, Juergen,Schlecker, Rainer
, p. 173 - 178 (2007/10/03)
Starting from different 14C-labelled compounds four isotopomers of the title compound epoxiconazole were synthesized.Chemical and radiochemical purities of the products were checked by radio-TLC and radio-HPLC and were found to be > 98percent - Key words:
