4'-fluoro-2,2-dimethoxyacetophenone

Base Information

• Chemical Name: 4'-fluoro-2,2-dimethoxyacetophenone
• CAS No.: 21983-80-2
• Molecular Formula: C10H11 F O3
• Molecular Weight: 198.194
• Hs Code.: 2914700090
• Mol file: 21983-80-2.mol

Synonyms:Glyoxal,(p-fluorophenyl)-, 2-(dimethyl acetal) (8CI);1-(4-Fluorophenyl)-2,2-dimethoxyethanone

Chemical Property of 4'-fluoro-2,2-dimethoxyacetophenone

Chemical Property:

• PSA: 35.53000
• LogP: 1.62730

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43-52/53
• Safety Statements: 24-37-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-fluoro-2,2-dimethoxyacetophenone

There total 4 articles about 4'-fluoro-2,2-dimethoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-trimethoxy-N-methyl-acetamide (1401816-27-0) + 4-fluorophenylmagnesium chloride (130387-74-5) → 1,1-dimethoxy-2-(4-fluorophenyl)-ethan-2-one (21983-80-2)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.3390/molecules171213864

Reference yield: 85.0%

methanol (67-56-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1,1-dimethoxy-2-(4-fluorophenyl)-ethan-2-one (21983-80-2)

Guidance literature:

With iodine; at 90 ℃; for 9h;

Reference yield:

methanol (67-56-1) + (4-fluorophenyl)glyoxal (403-32-7) → 1,1-dimethoxy-2-(4-fluorophenyl)-ethan-2-one (21983-80-2)

Guidance literature:

With thionyl chloride; In pyridine; at 20 ℃; Inert atmosphere; Molecular sieve; Cooling with ice; Schlenk technique;

DOI:10.1002/adsc.201700175

upstream raw materials:

methyl nitrite

1-(4-fluorophenyl)ethanone

N-trimethoxy-N-methyl-acetamide

4-fluorophenylmagnesium chloride

Downstream raw materials:

3-(4-fluorophenyl)-5,6-dihydropyrazin-2(1H)-one

methyl (p-fluorobenzoyl)formate

2-(4-fluorophenyl)-3-(2-chlorophenyl)propenal

E-2-(4-fluorophenyl)-3-(2-chlorophenyl)-propenal

Refernces

• 1、 Wang, Yanzhao,Liu, Yuanyuan,Li, Kun,Yang, Guoqiang,Zhang, Wanbin. "Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Piperazin-2-ones". supporting information. p. 1933 - 1941. Retrieved 2017/06/09.
• 2、 Burger, Tycho,Karbach, Stefan,Niemeyer, Juergen,Schlecker, Rainer. "Synthesis of Four 14C-Isotopomers of Epoxiconazole, a New Triazole Fungicide". . p. 173 - 178. Retrieved 2007/10/03.