21987-27-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Indole-5-carboxylic acid, 2,3-dimethyl-, methyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological and pharmacological activities. It contributes to the development of new drugs with therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 1H-Indole-5-carboxylic acid, 2,3-dimethyl-, methyl ester serves as a crucial component in the production of various agrochemicals, potentially enhancing crop protection and yield.
Used in Organic Material Synthesis:
1H-Indole-5-carboxylic acid, 2,3-dimethyl-, methyl ester is utilized as a building block in the synthesis of organic materials, where its unique structure and properties can be leveraged to create novel materials with specific applications.
Used as a Flavoring Agent:
1H-Indole-5-carboxylic acid, 2,3-dimethyl-, methyl ester is used as a flavoring agent in the food and beverage industry, adding unique taste profiles to products.
Used as a Fragrance Ingredient:
In the perfume industry, 1H-Indole-5-carboxylic acid, 2,3-dimethyl-, methyl ester is used as a fragrance ingredient, contributing to the creation of distinct and complex scents in perfumes and other fragranced products.

Upstream product

• 67-56-1 methanol 
• 62-23-7 4-nitro-benzoic acid 
• 14844-73-6 2,3-dimethyl-1H-indole-5-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 619-67-0 4-Hydrazinobenzoic acid 

Downstream Products

• 438218-59-8 1-ethyl-2,3-dimethylindole-5-carboxylic acid 

Relevant academic research and scientific papers

METHODS AND MATERIALS FOR INCREASING OR MAINTAINING NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE-2 (NMNAT2) POLYPEPTIDE LEVELS

This document provides methods and materials for increasing or maintaining NMNAT2 polypeptide levels within cells. For example, compounds (e.g., organic compounds) having the ability to increase or maintain NMNAT2 polypeptide levels within cells, formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for increasing or maintain NMNAT2 polypeptide levels within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in NMNAT2 polypeptide levels are provided (or for preventing said condition).

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Discovery of carbazole carboxamides as novel RORγt inverse agonists

A novel series of carbazole carboxamides was discovered as potent RORγt inverse agonists using a scaffold hybridization strategy. Structure-activity relationship exploration on the amide linker, carbazole ring and arylsulfone moiety of the hybrid amide 3a led to identification of potent RORγt inverse agonists. Compound 6c was found to have a good RORγt activity with an IC50 of 58.5 nM in FRET assay, and reasonable inhibitory activity in mouse Th17 cell differentiation assay (58.8% inhibition at 0.3 μM). The binding mode of carbazole carboxamides in RORγt ligand binding domain was discussed.

New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists

The preparation and evaluation of a novel class of CB2 agonists based on a 1,2,3,4-tetrahydropyrrolo[3,4-b]indole moiety are reported. They showed binding affinities up to 4.2 nM toward CB2 with sub-nanomolar EC50 values. They also showed moderate to good (>350-fold) selectivity over the CB1 receptor.

Bartoli indole synthesis on solid supports

(Matrix presented) Bartoli indole synthesis has been performed for the first time on solid supports. Starting from Merrifield resin, immobilization of five nitro benzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic c

Intramolecular cyclization reactions of unsaturated amino Fischer chromium carbenes forming indoles and quinolines

A thermally induced intramolecular annulation reaction of N-(2-alkenylphenyl)amino substituted Fischer chromium carbenes has been extensively examined. The carbene complexes were prepared in moderate to good yields by reaction of 2-aminostyrenes with intermediately formed acyloxy substituted carbenes. Upon heating, the thermally labile carbenes decomposed producing indoles and quinolines as the major products. The product distribution was found to be highly dependent on the substitution pattern and electronic properties of the starting material, and on the solvent used.