220033-62-5

Upstream product

• 104871-67-2 (R)-2-(p-tolylsulfinyl)-1-cyclohexanone 
• 103-19-5 di(p-tolyl) disulfide 
• 141-78-6 ethyl acetate 
• 220033-61-4 2,2-Bis-p-tolylsulfanyl-cyclohexanone 

Downstream Products

• 92016-16-5 2-Hydroxy-cyclohexanon-⁽¹⁾-essigsaeure-⁽²⁾-aethylester 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure (R)- and (S)-2-ethoxycarbonylmethyl- 2-hydroxy-cyclohexanones

Sulfenylation of 2-p-tolylsulfinyl cyclohexanone can be achieved at - 78°C with thiosulfonates. The in situ aldol reaction of these compounds with ethyl acetate enolate is highly stereoselective (1,2-asymmetric induction) and yields diastereomeric mixture