220043-81-2Relevant academic research and scientific papers
From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors
Pastor, Miryam,Zapico, José María,Coderch, Claire,Maslyk, Maciej,Panchuk, Rostyslav,De Pascual-Teresa, Beatriz,Ramos, Ana
, p. 916 - 929 (2019/01/30)
In this article, we describe our efforts in the search of MMP2/CK2 dual targeting inhibitors. We have followed a rational drug design approach based on our experience in the selective inhibition of these two enzymes. We have successfully obtained highly a
Carbon-11 labelling of an N-sulfonylamino acid derivative: A potential tracer for MMP-2 and MMP-9 imaging
Kuhnast, Bertrand,Bodenstein, Claudia,Wester, Hans Juergen,Weber, Wolfang
, p. 539 - 553 (2007/10/03)
Matrix metalloproteinases (MMPs) are a family of proteinases that play an important role in cancer. Non invasive imaging of MMPs would allow the evaluation of MMP activity in cancer and the assessment of the response of MMP inhibitor based therapies. In t
